IL1A 889 (+4845) C>T gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.
nr = not reported. = association not found. = association found. 63% Caucasian; 22% Asian; 15% Afro-Caribean. Cases diagnosed as adult periodontitis. Cases diagnosed as mixed periodontitis status. An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A 889, IL-1B +3954, and IL1RN in a subgroup of patients being nonsmokers, and at the same time culture negative for P. gingivalis and A. actinomycetemcomitans.