International Journal of Dentistry / 2010 / Article / Tab 1

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 1

IL1A 889 (+4845) C>T gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
EthnicitynR-alleleNR-alleleAssociatedReference
of subjectscarriagecarriagewith periodontitis

Caucasian32 43%3238% Gore et al.1998 [5]
Caucasian105 64%5360% Laine et al. 2001 [6]
Caucasian6143%80050% Thomson et al. 2001 [7]
Caucasian84 48%6045% Rogers et al. 2002 [8]
Caucasian4553%11043% Sakellari et al. 2003 [9]
Caucasian5772%10056% Brett et al. 2005 [10]
Caucasian330 44%10135% Lopez et al. 2005 [11]
Caucasian5654%9049% Sakellari et al. 2006 [12]
Caucasian5155%17843% Tervonen et al. 2007 [13]
Caucasian9790%9779% Wagner et al. 2007 [14]
Caucasian893 54%49349% Struch et al. 2008 [15]
Caucasian51 71%16860% Geismar et al. 2008 [16]
Mixed 8369%3752% Shirodaria et al. 2000 [17]
Asian (Thai)548%4323% Anusaksathien et al. 2003 [18]
Japanese58 14%4416% Kobayashi et al. 2007 [19]
Japanese100 20%10016% Kobayashi et al. 2007 [20]
Brazilian2914%1723% Gonçalves et al. 2006 [21]
Brazilian6760%4141% Moreira et al. 2007 [22]

nr = not reported. = association not found. = association found.
63% Caucasian; 22% Asian; 15% Afro-Caribean.
Cases diagnosed as adult periodontitis.
Cases diagnosed as mixed periodontitis status.
An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A 889, IL-1B +3954, and IL1RN in a subgroup of patients being nonsmokers, and at the same time culture negative for P. gingivalis and A. actinomycetemcomitans.