Gene Polymorphisms in Chronic Periodontitis

Table 11

CD14, TLR2, and TLR4 gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

		Patients		Controls
	Ethnicity	n	R-allele	n	R-allele	Associated	Reference
	of subjects		carriage		carriage	with periodontitis
CD14 −2601 C>T	Caucasian	135	74%	207	70%	−	Holla et al. 2002 [87]
	Caucasians	70	66%	75	76%	− (+^3)	Folwaczny et al. 2004 [88]
	Caucasian	60	67%	39	77%	+^4	Donati et al. 2005 [46]
	Caucasian2	100	74%	99	71%	+^5	Laine et al. 2005 [89]
	Caucasian	95	75%	94	77%	−	James et al. 2007 [90]
	Caucasian	51	47%	178	57%	− (+^6)	Tervonen et al. 2007 [13]
	Caucasian	60	67%	80	64%	−	Schulz et al. 2008 [91]
	Caucasian2	72	76%	35	80%	−	Nicu et al. 2009 [92]
	Non-Caucasian2	33	64%	22	86%	−
	Japanese	163	75%	104	82%	− (+^7)	Yamazaki et al. 2003 [93]
CD14 −1359	Caucasian	135	43%	207	42%	−	Holla et al. 2002 [87]
	Caucasian	95	38%	94	35%	−	James et al. 2007 [90]
TLR2 Arg677Trp	Caucasian	122	0%	122	0%	−	Folwaczny et al. 2004 [88]
	Caucasian	83	0%	106	0%	−	Berdeli et al. 2007 [94]
	Japanese	97	0%	100	0%	−	Fukusaki et al. 2007 [95]
	Chinese	50	100%	100	100%	−	Zhu et al. 2008 [96]
TLR2 Arg753Gln	Caucasian	122	3%	122	4%	−	Folwaczny et al. 2004 [88]
	Caucasian	83	13%	106	13%	−	Berdeli et al. 2007 [94]
	Japanese	97	0%	100	0%	−	Fukusaki et al. 2007 [95]
	Chinese	50	0%	100	6%	−	Zhu et al. 2008 [96]
TLR2 −183	Japanese	97	0%	100	1%	−	Fukusaki et al. 2007 [95]
TLR2 −148	Japanese	97	0%	100	1%	−	Fukusaki et al. 2007 [95]
TLR2 −146	Japanese	97	0%	100	1%	−	Fukusaki et al. 2007 [95]
TLR2 +1350	Japanese	97	40%	100	28%	−	Fukusaki et al. 2007 [95]
TLR2 +2343	Japanese	97	0%	100	3%	−	Fukusaki et al. 2007 [95]
TLR4 Asp299Gly	Caucasian	122	4%	122	3%	−	Folwaczny et al. 2004 [88]
	Caucasian	57	11%	100	7%	−	Brett et al. 2005 [10]
	Caucasian2	100	10%	99	9%	−	Laine et al. 2005 [89]
	Caucasian	83	5%	106	6%	−	Berdeli et al. 2007 [94]
	Caucasian	171	14%	218	11%	−	Holla et al. 2007 [97]
	Caucasian	95	19%	94	17%	−	James et al. 2007 [90]
	Caucasian	51	25%	178	20%	−	Tervonen et al. 2007 [13]
	Caucasian	60	13%	80	9%	−	Schulz et al. 2008 [91]
	Japanese	97	0%	100	0%	−	Fukusaki et al. 2007 [95]
	Chinese	50	0%	100	0%	−	Zhu et al. 2008 [96]
TLR4 Thr399Ile	Caucasian	122	4%	122	4%	−	Folwaczny et al. 2004 [88]
	Caucasian	57	7%	100	18%	−	Brett et al. 2005 [10]
	Caucasian2	100	10%	99	9%	−	Laine et al. 2005 [89]
	Caucasian	83	4%	106	5%	−	Berdeli et al. 2007 [94]
	Caucasian	171	14%	218	10%	−	Holla et al. 2007 [97]
	Caucasian	95	22%	94	20%	−	James et al. 2007 [90]
	Caucasian	60	13%	80	9%	−	Schulz et al. 2008 [91]
	Japanese	97	0%	100	0%	−	Fukusaki et al. 2007 [95]
	Chinese	50	0%	100	0%	−	Zhu et al. 2008 [96]
TLR4 +3528	Japanese	97	0%	100	2%	−	Fukusaki et al. 2007 [95]
TLR4 +3525	Japanese	97	26%	100	29%	+	Fukusaki et al. 2007 [95]
TLR4 +4022	Japanese	97	0%	100	1%	−	Fukusaki et al. 2007 [95]
TLR4 +4529	Japanese	97	2%	100	1%	−	Fukusaki et al. 2007 [95]

nr = not reported. − = association not found. + = association found.
1Also refered as −159.
2Cases diagnosed as adult periodontitis.
3The N-allele is associated with periodontitis in women.
4The N-allele is associated with CP.
5The R/R genotype is associated with CP also after correcting for age, gender, smoking, and presence A. actinomytemcomitans and P. gingivalis.
6The R-allele is associated with disease severity.
7The R-allele associated with early disease development.