International Journal of Dentistry / 2010 / Article / Tab 11

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 11

CD14, TLR2, and TLR4 gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
  EthnicitynR-allelenR-alleleAssociatedReference
of subjectscarriagecarriagewith periodontitis

CD14 260 C>TCaucasian13574%20770% Holla et al. 2002 [87]
Caucasians7066%7576% ( )Folwaczny et al. 2004 [88]
Caucasian6067%3977% Donati et al. 2005 [46]
Caucasian 10074%9971% Laine et al. 2005 [89]
Caucasian9575%9477% James et al. 2007 [90]
Caucasian5147%17857% ( )Tervonen et al. 2007 [13]
Caucasian6067%8064% Schulz et al. 2008 [91]
Caucasian 7276%3580% Nicu et al. 2009 [92]
Non-Caucasian 3364%2286%
Japanese16375%10482% ( )Yamazaki et al. 2003 [93]

CD14 1359Caucasian13543%20742% Holla et al. 2002 [87]
Caucasian9538%9435% James et al. 2007 [90]

TLR2 Arg677TrpCaucasian1220%1220% Folwaczny et al. 2004 [88]
Caucasian830%1060% Berdeli et al. 2007 [94]
Japanese970%1000% Fukusaki et al. 2007 [95]
Chinese50100%100100% Zhu et al. 2008 [96]

TLR2 Arg753GlnCaucasian1223%1224% Folwaczny et al. 2004 [88]
Caucasian8313%10613% Berdeli et al. 2007 [94]
Japanese970%1000% Fukusaki et al. 2007 [95]
Chinese500%1006% Zhu et al. 2008 [96]

TLR2 183Japanese970%1001% Fukusaki et al. 2007 [95]

TLR2 148Japanese970%1001% Fukusaki et al. 2007 [95]

TLR2 146Japanese970%1001% Fukusaki et al. 2007 [95]

TLR2 +1350Japanese9740%10028% Fukusaki et al. 2007 [95]

TLR2 +2343Japanese970%1003% Fukusaki et al. 2007 [95]

TLR4 Asp299GlyCaucasian1224%1223% Folwaczny et al. 2004 [88]
Caucasian5711%1007% Brett et al. 2005 [10]
Caucasian 10010%999% Laine et al. 2005 [89]
Caucasian835%1066% Berdeli et al. 2007 [94]
Caucasian17114%21811% Holla et al. 2007 [97]
Caucasian9519%9417% James et al. 2007 [90]
Caucasian5125%17820% Tervonen et al. 2007 [13]
Caucasian6013%809% Schulz et al. 2008 [91]
Japanese970%1000% Fukusaki et al. 2007 [95]
Chinese500%1000% Zhu et al. 2008 [96]

TLR4 Thr399IleCaucasian1224%1224% Folwaczny et al. 2004 [88]
Caucasian577%10018% Brett et al. 2005 [10]
Caucasian 10010%999% Laine et al. 2005 [89]
Caucasian834%1065% Berdeli et al. 2007 [94]
Caucasian17114%21810% Holla et al. 2007 [97]
Caucasian9522%9420% James et al. 2007 [90]
Caucasian6013%809% Schulz et al. 2008 [91]
Japanese970%1000% Fukusaki et al. 2007 [95]
Chinese500%1000% Zhu et al. 2008 [96]
TLR4 +3528Japanese970%1002% Fukusaki et al. 2007 [95]

TLR4 +3525Japanese9726%10029% Fukusaki et al. 2007 [95]

TLR4 +4022Japanese970%1001% Fukusaki et al. 2007 [95]

TLR4 +4529Japanese972%1001% Fukusaki et al. 2007 [95]

nr = not reported. = association not found. = association found.
Also refered as 159.
Cases diagnosed as adult periodontitis.
The N-allele is associated with periodontitis in women.
The N-allele is associated with CP.
The R/R genotype is associated with CP also after correcting for age, gender, smoking, and presence A. actinomytemcomitans and P. gingivalis.
The R-allele is associated with disease severity.
The R-allele associated with early disease development.