International Journal of Dentistry / 2010 / Article / Tab 12

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 12

Miscellaneous candidate genes and the corresponding encoded proteins studied in relation to susceptibility to chronic periodontitis and reported association.

PolymorphismCoded proteinReferenceAssociated
in genewith periodontitis

ACEAngiotensin-converting enzymeHolla et al. 2001 [98] ( )
BPIBactericidal/permeability-increasing proteinGlas et al. 2006 [99]
CARD15 (NOD2)Caspase recruitment domain-15Folwaczny et al. 2004 [100]
Laine et al. 2004 [101]
CCR5Chemokine receptor-5Folwaczny et al. 2003 [102]
Wohlfahrt et al. 2006 [59]
Savarrio et al. 2007 [103]

COL1A1Type 1 collagenSakellari et al. 2006 [12]
COX-2Cyclooxygenase-2Ho et al. 2008 [104]
Xie et al. 2009 [105]

CTLA-4Cytotoxic T-lymphocyte antigen-4Wohlfahrt et al. 2006 [59]
DEFB1Human β ̣ defensin ̣1Wohlfahrt et al. 2006 [59]
eNOSEndothelial nitric oxide synthaseBerdeli et al. 2006 [106]
ER2Estrogen receptor-2Zhang et al. 2004 [107]
E-selectinE-selectinHoushmand et al. 2009 [108]
ET1Endothelin-1Holla et al. 2001 [98]
FasLFas ligandWohlfahrt et al. 2006 [59]
FBRFibrinogenSahingur et al. 2003 [109]
Fc RIIbFc receptor IIbYasuda et al. 2003 [110]
Kobayashi et al. 2007 [19]

GSTM1Glutathione-S-transferase M1Concolino et al. 2007 [111]

GSTT1Glutathione-S-transferase T1Concolino et al. 2007 [111]

ICAM-1Intercellular adhesion molecule-1Wohlfahrt et al. 2006 [59]

ICOSInducible costimulatorWohlfahrt et al. 2006 [59]

IFNGInterferon Hooshmand et al. 2008 [52]
Reichert et al. 2008 [112]

IFNGR1Interferon receptor-1Fraser et al. 2003 [113] ( )
Babel et al. 2006 [58]

IL2Interleukin-2Scarel-Caminaga et al. 2002 [114]

IL12Interleukin-12Reichert et al. 2008 [112]
IL12RB2Takeuchi-Hatanaka et al. 2008 [115]

IL16Interleukin-16Folwaczny et al. 2005 [116]
IL18Interleukin-18Folwaczny et al. 2005 [117]
IL24 Interleukin-24Savarrio et al. 2007 [103]
LactoferrinLactoferrinWu et al. 2009 [118]
L-selectinL-selectinHoushmand et al. 2009 [108]
LTALymphotoxin- Holla et al. 2001 [98]
Fassmann et al. 2003 [44] ( )

MBLMannose binding lectinLouropoulou et al. 2008 [119]
Tsutsumi et al. 2009 [120]

MMP1Matrix metalloproteinase-1de Souza et al. 2003 [121] ( )
Holla et al. 2004 [122]
Itagaki et al. 2004 [123]
Astolfi et al. 2006 [124]
Cao et al. 2006 [125]
Pirhan et al. 2008 [126]
Ustun et al. 2008 [127]
MMP2Matrix metalloproteinase-1 (gelatinase A)Holla et al. 2005 [128]
Gurkan et al. 2008 [129]

MMP3Matrix metalloproteinase-3Itagaki et al. 2004 [123]
Astolfi et al. 2006 [124]

MMP9Matrix metalloproteinase-9de Souza et al. 2005 [130]
Holla et al. 2006 [131]
Keles et al. 2006 [132]
Gurkan et al. 2008 [129]

MMP12Matrix metalloproteinase-12Gurkan et al. 2008 [129]
MPOMyeloperoxidaseMeisel et al. 2002 [133] ( )
NAT2N-acetyltransferase-2Meisel et al. 2000 [134]
Kocher et al. 2002 [135]

OPGOsteoprotegerinWohlfahrt et al. 2006 [59]
Wagner et al. 2007 [14]
Baioni et al. 2008 [136]
Park et al. 2008 [137] ( )

OPNOsteopontinWohlfahrt et al. 2006 [59]
PAI1Plasminogen-activator-inhibitor-1Holla et al. 2002 [138]
Gurkan et al. 2007 [139]

RAGEReceptor for advanced glycation end productsHolla et al. 2001 [140]
RANTESRegelated on activation, normal T cells expressed and secretedSavarrio et al. 2007 [103]
S100A8 CalprotectinLi et al. 2007 [141]
SFTPDSurfactant protein DGlas et al. 2008 [142]
TGFB1Transforming growth factor- Holla et al. 2002 [143]
de Souza et al. 2003 [144]
Atilla et al. 2006 [145]
Babel et al. 2006 [58]

TIMP2Tissue inhibitor of matrix metalloproteinasede Souza et al. 2005 [130]
TNFR2Tumor necrosis factor receptor-2Shimada et al. 2004 [146]
-PATissue plasminogen-activatorGurkan et al. 2007 [139]

= association not found. = association found.
in combination with LTA.
R-allele associated with higher serum fibrinogen.
R-allele in combination with smoking.
N-allele protective in combination with TNFA-308.
R-allele associated in non-smokers.
R-allele protective for females.
950T and 1181G haplotype is associated with CP.
N-allele of rs3795391and rs3806232 is associated with CP in Chinese males.
R-allele of codon 25 associated with CP.