Gene Polymorphisms in Chronic Periodontitis

Table 2

IL1B +3954 (+3953) C>T gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

	Patients		Controls
Ethnicity	n	R-allele	n	R-allele	Associated	Reference
of subjects		carriage		carriage	with periodontitis
Caucasian	321	43%	32	38%	−	Gore et al. 1998 [5]
Caucasian	401	50%	45	27%	+	Galbraith et al. 1999 [25]
Caucasian	1051	49%	53	45%	−(+^3)	Laine et al. 2001 [6]
Caucasian	61	34%	800	41%	−	Thomson et al. 2001 [7]
Caucasian	841	35%	60	40%	+^4	Rogers et al. 2002 [8]
Caucasian	281	46%	33	48%	−	Gonzales et al. 2003 [26]
Caucasian	45	49%	110	50%	−	Sakellari et al. 2003 [9]
Caucasian	57	42%	100	41%	−	Brett et al. 2005 [10]
Caucasian	3302	30%	101	13%	+	Lopez et al. 2005 [11]
Caucasian	32	34%	52	40%	−	Droździk et al. 2006 [27]
Caucasian	13	33%	13	33%	−	Gustafsson et al. 2006 [28]
Caucasian	56	41%	90	44%	−	Sakellari et al. 2006 [12]
Caucasian	51	49%	178	44%	−	Tervonen et al. 2007 [13]
Caucasian	97	74%	97	43%	+	Wagner et al. 2007 [14]
Caucasian	511	57%	168	43%	−	Geismar et al. 2008 [16]
Caucasian	8931	44%	493	39%	−^5	Struch et al. 2008 [15]
Asian (Thai)	54	0%	43	2%	−	Anusaksathien et al. 2003 [18]
Japanese	641	6%	64	10%	−	Soga et al. 2003 [29]
Japanese	582	5%	44	7%	−	Kobayashi et al. 2007 [19]
Japanese	1002	6%	100	6%	−	Kobayashi et al. 2007 [20]
Brazilian	52	44%	31	23%	+	Moreira et al. 2005 [30]
Brazilian	29	28%	17	18%	−	Gonçalves et al. 2006 [21]
Brazilian	117	39%	175	31%	−	Ferreira et al. 2008 [31]
Indian	30	30%	31	23%	−	Kaarthikeyan et al. 2009 [32]

nr = not reported. − = association not found. + = association found.
1Cases diagnosed as adult periodontitis.
2Cases diagnosed as mixed periodontitis status.
3An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A −889, IL1B +3954, and IL1RN in a subgroup of patients being nonsmokers, and at the same time culture negative for P. gingivalis and A. actinomycetemcomitans.
4N-allele is associated with CP.
5R-allele is not quit associated with CP (𝑃=.07).