Gene Polymorphisms in Chronic Periodontitis

Table 3

IL1B −511 (−31) and IL1RN VNTR (+2018) gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

		Patients		Controls
IL1 gene	Ethnicity of subjects	n	R-allele	n	R-allele	Associated	Reference
polymorphism			carriage		carriage	with periodontitis
B −511 (−31) C>T	Caucasian	321	59%	32	59%	−	Gore et al. 1998 [5]
	Caucasian	57	53%	100	49%	−	Brett et al. 2005 [10]
	Caucasian	511	43%	168	56%	−	Geismar et al. 2008 [16]
	Japanese	641	67%	64	78%	−	Soga et al. 2003 [29]
RN VNTR (+2018 C>T)	Caucasian	1051	46%	53	38%	− (+^3)	Laine et al. 2001 [6]
	Caucasian	51	45%	190	7%	+	Berdeli et al. 2006 [35]
	Caucasian	56	45%	90	30%	−	Sakellari et al. 2006 [12]
	Caucasian	511	34%	168	44%	−	Geismar et al. 2008 [16]
	Japanese	1002	6%	100	13%	−	Kobayashi et al. 2007 [20]

nr = not reported. − = association not found. + = association found.
1Cases diagnosed as adult periodontitis.
2Cases diagnosed as mixed periodontitis status.
3An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A −889, IL1B +3954, and IL1RN in a subgroup of patients being non-smokers and culture negative for P. gingivalis and A. actinomycetemcomitans.