International Journal of Dentistry / 2010 / Article / Tab 3

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 3

IL1B 511 ( 31) and IL1RN VNTR (+2018) gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
IL1 geneEthnicity of subjectsnR-allelenR-alleleAssociatedReference
polymorphismcarriagecarriagewith periodontitis

B 511 ( 31) C>TCaucasian32 59%3259% Gore et al. 1998 [5]
Caucasian5753%10049% Brett et al. 2005 [10]
Caucasian51 43%16856% Geismar et al. 2008 [16]
Japanese64 67%6478% Soga et al. 2003 [29]

RN VNTR (+2018 C>T)Caucasian105 46%5338% ( )Laine et al. 2001 [6]
Caucasian5145%1907% Berdeli et al. 2006 [35]
Caucasian5645%9030% Sakellari et al. 2006 [12]
Caucasian51 34%16844% Geismar et al. 2008 [16]
Japanese100 6%10013% Kobayashi et al. 2007 [20]

nr = not reported. = association not found. = association found.
Cases diagnosed as adult periodontitis.
Cases diagnosed as mixed periodontitis status.
An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A 889, IL1B +3954, and IL1RN in a subgroup of patients being non-smokers and culture negative for P. gingivalis and A. actinomycetemcomitans.