Gene Polymorphisms in Chronic Periodontitis

Table 4

IL1 composite genotype, that is, Rare (R)-allele carriage at IL1A −889 (+4845) and IL1B +3954 (+3953) [36], in case-control studies and association with susceptibility to chronic periodontitis.

	Patients		Controls
Ethnicity	n	R-allele	n	R-allele	Associated	Reference
of subjects		carriage		carriage	with periodontitis
Caucasian	322	34%	32	28%	−	Gore et al. 1998 [5]
Caucasian1	44	41%	46	28%	+	McDevitt et al. 2000 [37]
Caucasian	1052	46%	53	42%	−	Laine et al. 2001 [6]
Caucasian	1323	45%	73	42%	−	Papapanou et al. 2001 [38]
Caucasian	61	28%	800	35%	−	Thomson et al. 2001 [7]
Caucasian	842	26%	60	30%	−	Rogers et al. 2002 [8]
Caucasian	402	38%	414	34%	− (+^4)	Meisel et al. 2003 [39]
Caucasian	45	34%	110	30%	−	Sakellari et al. 2003 [9]
Caucasian	3303	26%	101	10%	+	Lopez et al. 2005 [11]
Caucasian	56	41%	90	44%	−	Sakellari et al. 2006 [12]
Chinese	2442	0%	56	3%	−	Armitage et al. 2000 [40]
Asian (Thai)	54	0%	43	2%	−	Anusaksathien et al. 2003 [18]
Japanese	1003	0.2%	100	0.2%	−	Kobayashi et al. 2007 [20]
Indian	90	14%	30	0%	+	Agrawal et al. 2006 [41]
Brazilian	29	3%	17	12%	−	Gonçalves et al. 2006 [21]

nr = not reported. − = association not found. + = association found.
182% of study population is of Caucasian heritage; results found after multiple logistic regression analysis correcting for smoking status and age.
2Cases diagnosed as adult periodontitis.
3Cases diagnosed as mixed periodontitis status.
4In smokers.