International Journal of Dentistry / 2010 / Article / Tab 4

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 4

IL1 composite genotype, that is, Rare (R)-allele carriage at IL1A 889 (+4845) and IL1B +3954 (+3953) [36], in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
EthnicitynR-allelenR-alleleAssociatedReference
of subjectscarriagecarriagewith periodontitis

Caucasian32 34%3228% Gore et al. 1998 [5]
Caucasian 4441%4628% McDevitt et al. 2000 [37]
Caucasian105 46%5342% Laine et al. 2001 [6]
Caucasian132 45%7342% Papapanou et al. 2001 [38]
Caucasian6128%80035% Thomson et al. 2001 [7]
Caucasian84 26%6030% Rogers et al. 2002 [8]
Caucasian40238%41434% ( )Meisel et al. 2003 [39]
Caucasian4534%11030% Sakellari et al. 2003 [9]
Caucasian330 26%10110% Lopez et al. 2005 [11]
Caucasian5641%9044% Sakellari et al. 2006 [12]
Chinese244 0%563% Armitage et al. 2000 [40]
Asian (Thai)540%432% Anusaksathien et al. 2003 [18]
Japanese100 0.2%1000.2% Kobayashi et al. 2007 [20]
Indian9014%300% Agrawal et al. 2006 [41]
Brazilian293%1712% Gonçalves et al. 2006 [21]

nr = not reported. = association not found. = association found.
82% of study population is of Caucasian heritage; results found after multiple logistic regression analysis correcting for smoking status and age.
Cases diagnosed as adult periodontitis.
Cases diagnosed as mixed periodontitis status.
In smokers.