International Journal of Dentistry / 2010 / Article / Tab 7

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 7

IL6 and IL6R gene polymorphisms and carriage of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
IL6 geneEthnicitynR-allelenR-alleleAssociatedReference
polymorphismof subjectscarriagecarriagewith periodontitis

−174 G>CCaucasian14877%10784% Holla et al. 2004 [57]
Caucasian5761%10044% Brett et al. 2005 [10]
Caucasian12442%11628% Babel et al. 2006 [58]
Caucasian13765%8262% Wohlfahrt et al. 2006 [59]
Caucasian5178%17879% Tervonen et al. 2007 [13]
Caucasian32661%14471%
Afro-American9310%4516% Nibali et al. 2009 [60]
Asian8720%2924%
Brazilian4837%3667% Trevilatto et al. 2003 [61]
Japanese1120%770% Komatsu et al. 2005 [62]
Brazilian155 44%5437% Moreira et al. 2007 [63]

190 C>TJapanese1120%770% Komatsu et al. 2005 [62]

−572 C>G    Caucasian1486%10720% Holla et al. 2004 [57]
Japanese11237%7747% Komatsu et al. 2005 [62]
Caucasian32610%1448%
Afro-American9321%4513% Nibali et al. 2009 [60]
Asian8761%2955%

373Japanese11212%7721% Komatsu et al. 2005 [62]
(A(n)T(m)(A9T11)(A9T11)

597 G>ACaucasian14878%10784% Holla et al. 2004 [57]
Japanese1120%770% Komatsu et al. 2005 [62]

−1363 G>T  Caucasian32614%14422%
Afro-American931%454% Nibali et al. 2009 [60]
Asian875%2914%

−1480 C>G  Caucasian32658%14456%
Afro-American938%4516% Nibali et al. 2009 [60]
Asian8719%2924%

−6106 A>T  Caucasian32638%14437%
Afro-American9336%4538% Nibali et al. 2009 [60]
Asian8738%2948%

R +48892 A>CJapanese16966%7066% ( )Galicia et al. 2006 [64]

R −183 G>AJapanese16976%7074% Galicia et al. 2006 [64]

nr = not reported. = association not found. = association found.
Cases diagnosed as mixed periodontitis status.
Only R/R genotype frequency is reported and is associated with CP
IL-6 174, 1363, and 1480 haplotype is associated with periodontitis.
N/N genotype is associated with CP.
Carriage rate of the 373 A9T11 allele higher in non-CP.
N-allele is associated with CP.