International Journal of Dentistry / 2010 / Article / Tab 8

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 8

IL10 gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
IL10 geneEthnicitynR-allelenR-alleleAssociatedReference
polymorphismof subjectscarriagecarriagewith periodontitis

1087 ( 1082) A>G Caucasian6077%3969% ( )Berglundh et al. 2003 [65]
Caucasian5767%10069% Brett et al. 2005 [10]
Caucasian11869%11474% Babel et al. 2006 [58]
Caucasian5163%17870% Tervonen et al. 2007 [13]
Caucasian2781%3470% Reichert et al. 2008 [66]  
Mixed 6749%4361% Scarel-Caminaga et al. 2004 [67]
(Caucasian)(48)(44%)(36)(61%)

819 ( 824) C>TCaucasian2726%3432% Reichert et al. 2008 [66]
Mixed 6776%4351% Scarel-Caminaga et al. 2004 [67]
(Caucasian)(48)(77%)(36)(47%)
Turkish7556%7345% Sumer et al. 2007 [68]

627 C>ACaucasian5732%10040% Brett et al. 2005 [10]

592 ( 597) C>A Mixed 67 72% 43 51%   Scarel-Caminaga et al. 2004 [67]
(Caucasian)(48)(75%)(36)(47%)
Mixed 11671%17351% Claudino et al. 2008 [69]
Turkish7568%7341% Sumer et al. 2007 [68]

590 C>ACaucasian2726%3432% Reichert et al. 2008 [66]

nr = not reported. = association not found. = association found.
76% of CP and 84% of the control population were Caucasians.
78% of CP and 79% of the control population were Caucasians.
N-allele associated with periodontitis, in particular non-smoking homozygous N/N subjects.