Gene Polymorphisms in Chronic Periodontitis

Table 8

IL10 gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

		Patients		Controls
IL10 gene	Ethnicity	n	R-allele	n	R-allele	Associated	Reference
polymorphism	of subjects		carriage		carriage	with periodontitis
−1087 (−1082) A>G	Caucasian	60	77%	39	69%	− (+^3)	Berglundh et al. 2003 [65]
	Caucasian	57	67%	100	69%	−	Brett et al. 2005 [10]
	Caucasian	118	69%	114	74%	−	Babel et al. 2006 [58]
	Caucasian	51	63%	178	70%	−	Tervonen et al. 2007 [13]
	Caucasian	27	81%	34	70%	−	Reichert et al. 2008 [66]
	Mixed1	67	49%	43	61%	0𝑥02012	Scarel-Caminaga et al. 2004 [67]
	(Caucasian)	(48)	(44%)	(36)	(61%)	(−)
−819 (−824) C>T	Caucasian	27	26%	34	32%	−	Reichert et al. 2008 [66]
	Mixed1	67	76%	43	51%	+	Scarel-Caminaga et al. 2004 [67]
	(Caucasian)	(48)	(77%)	(36)	(47%)	(+)
	Turkish	75	56%	73	45%	−	Sumer et al. 2007 [68]
−627 C>A	Caucasian	57	32%	100	40%	−	Brett et al. 2005 [10]
−592 (−597) C>A	Mixed1	67	72%	43	51%	+	Scarel-Caminaga et al. 2004 [67]
	(Caucasian)	(48)	(75%)	(36)	(47%)	(+)
	Mixed2	116	71%	173	51%	+	Claudino et al. 2008 [69]
	Turkish	75	68%	73	41%	+	Sumer et al. 2007 [68]
−590 C>A	Caucasian	27	26%	34	32%	−	Reichert et al. 2008 [66]

nr = not reported. − = association not found. + = association found.
176% of CP and 84% of the control population were Caucasians.
278% of CP and 79% of the control population were Caucasians.
3N-allele associated with periodontitis, in particular non-smoking homozygous N/N subjects.