International Journal of Dentistry / 2012 / Article / Fig 3

Review Article

The Current and Future Therapies of Bone Regeneration to Repair Bone Defects

Figure 3

A model of NF-κB-mediated inhibition of BMP/Smad-mediated DNA binding activity. NF-κB, particularly the p65 subunit, binds the Smad1/Smad4 complex directly or indirectly, and that this binding interferes with the DNA binding of Smad proteins induced by BMP-2.

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