Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds

Figure 3

Local regeneration of the dentin-pulp complex in dentin defect area by implantation of gelatin hydrogels incorporating FGF-2. (a) Gelatin hydrogels incorporating FGF-2 with collagen sponge are implanted into dentin defect area. Controlled release of FGF-2 from biodegraded gelatin hydrogels can induce pulp stem cells or progenitor cells, as well as vessels, into collagen sponge at defect, resulting in the regeneration of pulp in the defect area and the formation of regenerative dentin on surface of the new pulp. (b) Histological photograph of proliferating pulp and newly regenerated dentin at surface of proliferating pulp. (c) High magnification of the regenerated dentin.