Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds
Figure 4
Application of hyaluronic acid sponge for local regeneration of the dentin-pulp complex. (a) KN-3 cells, odontoblastic progenitor cells, adhered to hyaluronic acid sponge, as well as collagen sponge. (b) Histological changes of amputated dental pulp after implantation of hyaluronic acid sponge in vivo. Amputated dental pulp well proliferated into hyaluronic acid and collagen sponges. Compared with collagen sponge, hyaluronic acid sponge significantly suppressed inflammatory reaction of dental pulp.
(a) Cell Adhesion on Sponges
(b) Pulp proliferation and inflammatory reaction in sponges at defects