Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone

Figure 4

Histological observation before and after the transplantation of MSCs to artificial jaw cleft. The regenerated tissues were separated 3 and 6 months after the transplantation. Tissue sections were made and stained with hematoxylin and eosin (HE). Intraoral images 3 months after the transplantation on (a) the control side (CAP alone) and (b) the experimental side (MSCs and CAP particles). The tissue section showed fibroblastic cells and inflammatory cells around CAP particles on the control side (c, d, and e). New bone formation was shown widely on the experimental side (f, g, and h). Intraoral images 6 months after the transplantation on (i) the control side and (j) the experimental side. The tissue section showed that new bone formation had occurred locally on the control side (k, l, and m). On the other hand, new bone formation was observed in almost the whole area on the experimental side (n and o).