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International Journal of Dentistry
Volume 2012, Article ID 896143, 8 pages
Clinical Study

A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices

1GlaxoSmithKline Consumer Healthcare, Surrey Weybridge, KT13 0DE, UK
2Sino-American Tianjin SmithKline and French Laboratories Ltd., Beijing, China
3Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, LuoYu Road 237, Wuhan 430070, China
4Genesis Oral Bioscience, Consultancy & Scientific Writing, Regents Mews, Surrey, Horley RH6 7AN, UK

Received 27 August 2012; Revised 21 October 2012; Accepted 21 October 2012

Academic Editor: Michelle A. Chinelatti

Copyright © 2012 Ashley P. Barlow et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO3 and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects ( ), stratified into two groups ( ), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant ( ). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks ( , Dentifrice A; , Dentifrice B).