Association between IFN-γ +874A/T and IFN-γR1 (-611A/G, +189T/G, and +95C/T) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population

Table 5

The genotypes and allele distribution of IFN-γ/IFN-γR1 polymorphisms in chronic periodontitis (CP) patients and controls.

Polymorphism	CP	Controls	OR 95% (CI)	value
IFN-γ +874A/T
AA	71 (33.8%)	20 (20%)	2.420 (CI = 1.063–5.511)	0.035
AT	117 (55.7%)	65 (65%)	1.227 (CI = 0.596–2.529)	0.579
TT	22 (10.5%)	15 (15%)	—	Ref = 1
Alleles
A	259 (61.7%)	105 (52.5%)	1.455 (CI = 1.036–2.045)	0.031
T	161 (38.3%)	95 (47.5%)	—	Ref = 1
IFN-γR1 -611A/G
AA	67 (31.9%)	33 (33%)	0.883 (CI = 0.452–1.726)	0.715
GA	97 (46.2%)	47 (47%)	0.923 (CI = 0.450–1.893)	0.826
GG	46 (21.9%)	20 (20%)	—	Ref = 1
Alleles
A	231 (55%)	113 (56.5%)	0.941 (CI = 0.670–1.321)	0.725
G	189 (45%)	87 (43.5%)	—	Ref = 1
IFN-γR1 +189T/G
GG	23 (11%)	8 (8%)	1.426 (CI = 0.603–3.370)	0.419
GT	62 (29.5%)	30 (30%)	1.025 (CI = 0.602–1.744)	0.927
TT	125 (59.5%)	62 (62%)	—	Ref = 1
Alleles
G	108 (25.7%)	46 (23%)	1.159 (CI = 0.780–1.721)	0.465
T	312 (74.3%)	154 (77%)	—	Ref = 1
IFN-γR1 +95C/T
CC	54 (25.7%)	24 (24%)	—	Ref = 1
TC	95 (45.2%)	48 (48%)	0.880 (CI = 0.486–1.592)	0.672
TT	61 (29%)	28 (28%)	0.968 (CI = 0.502–1.867)	0.923
Alleles
C	203 (48.3%)	96 (48%)	—	Ref = 1
T	217 (51.7%)	104 (52%)	0.987 (CI = 0.704–1.382)	0.938

OR: odd ratio; CI: confidence interval.