Clinical Study
Amoxicillin/Clavulanic Acid for the Treatment of Odontogenic Infections: A Randomised Study Comparing Efficacy and Tolerability versus Clindamycin
Table 2
Primary efficacy endpoint: clinical success outcome at the end of the study.
| Population |
Clindamycin [% (95% CI)] |
Amoxicillin/clavulanic acid [% (95% CI)] | Treatment difference | Miettinen and Nurminen method (primary) [% (95% CI)] | Farrington and Manning method [% (95% CI)] | Two-sample proportion test [% (95% CI)] |
| PP | 89.7% (84.6%, 93.5%) | 88.2% (83.0%, 92.2%) | 1.5% ( 95 CI: −4.7%, 7.7%) | 1.5% (−4.9%, 8.0%) | 1.5% (−4.5%, 7.6%) |
| ITT-E | 86.4% (81.3%, 90.5%) | 85.5% (80.3%, 89.8%) | 0.9% (−5.5%, 7.3%) | 0.9% (−5.6%, 7.4%) | 0.9% (−5.5%, 7.2%) |
| ITT (randomised treatment arm) | 85.7% (80.5%, 89.9%) | 83.3% (77.9%, 87.9%) | 2.3% (−4.3%, 9.0%) | 2.3% (−4.4%, 9.0%) | 2.3% (−4.2%, 8.9%) |
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