Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience

Figure 4

Histopathological features of MRONJ in a patient treated by denosumab. Abundant inflammatory cell infiltration and basophilic bacterial colonies (A) interspersed with necrotic debris are evident. Also, nonnecrotic tissues containing larger amounts of lamellar bone (B), fewer and smaller Haversian canals (C), and larger and thicker osteons are detectable. Haematoxylin-Eosin, 10x.