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International Journal of Dentistry
Volume 2016, Article ID 3719879, 10 pages
Review Article

Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review

1Laboratory of Biology and Biochemistry Plants (BIOqPLANT), Federal University of Piaui, Parnaiba, PI, Brazil
2Laboratory of Histological Analysis and Prepare (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil
3Department of Morphology, LABICONTE, Federal University of Ceara, Fortaleza, CE, Brazil

Received 1 June 2016; Revised 22 June 2016; Accepted 23 June 2016

Academic Editor: Gul Atilla

Copyright © 2016 Jefferson Soares de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this systematic review was to investigate the advances in the study of medicinal plants and their biologic effects on periodontitis in animal models. Study Design. A systematic search was conducted by three independent researchers, who screened articles published up to March/2016, to identify the studies that contained sufficient and clear information on the association of the medicinal plants and periodontitis in murine models. The searches were performed using PubMed, Cochrane, and Science Direct databases. Results. After a critical analysis of titles and abstracts, 30 studies were finally eligible for analysis. The studies presented a great diversity of the experiment designed regarding the methods of induced periodontitis and the evaluation of the medicinal plants efficacy. None of the studies described the possible toxic effects associated with the administration of the plant material to animals and whether they could prevent damage to organs caused by systemic effect of induced periodontitis. Gel-based formulations containing plant substances are seen as an interesting strategy to treat periodontitis. Conclusions. In this systematic review, the state-of-the-art knowledge on the medicinal plants and the induced periodontitis was critically evaluated and discussed from the experiment designed to the possible clinical application.