Subchronic Infection of Porphyromonas gingivalis and Tannerella forsythia Stimulates an Immune Response but Not Arthritis in Experimental Murine Model

Figure 2

(a) Effect of the inoculation of periodontopathogenic bacteria on serum IL-6 levels. The values shown are the mean of three mice analyzed by study group plus their respective mean. Group 1: untreated sham; Group 2: mice inoculated with Pg/Tf; Group 3: inoculated intradermally with CFA + Pg/Tf; and Group 4: CFA inoculated intradermally. These values show a significant increase in IL-6 levels of Group 1 versus Group 2, although a significant difference was not demonstrated () in contrast with Group 3 (). A significant difference was found in Group 1 versus Group 4 (). (b) Effect of the inoculation of periodontopathogenic bacteria on serum levels of IL-1β. Murine blood was drawn on day 35 after euthanasia and was centrifuged and analyzed the next day. IL-1β in the supernatant was determined by ELISA. Groups: 1, 2, 3, 4. Bars represent the mean ± standard deviation of three replicates from three animals per group; these did not show statistically significant increases. PRISM v.6.0 was used for data analysis.

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