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International Journal of Dentistry
Volume 2017, Article ID 7285656, 10 pages
https://doi.org/10.1155/2017/7285656
Research Article

Lymphangiogenesis in Oral Squamous Cell Carcinoma: Correlation with VEGF-C Expression and Lymph Node Metastasis

1Department of Oral and Maxillofacial Pathology, Faculty of Oral & Dental Medicine, Cairo University, Giza, Egypt
2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt

Correspondence should be addressed to Manar A. Abdul-Aziz; moc.oohay@ssinaw.m

Received 29 December 2016; Revised 20 April 2017; Accepted 14 May 2017; Published 7 June 2017

Academic Editor: Tommaso Lombardi

Copyright © 2017 Manar A. Abdul-Aziz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Napier and P. M. Speight, “Natural history of potentially malignant oral lesions and conditions: An overview of the literature,” Journal of Oral Pathology and Medicine, vol. 37, no. 1, pp. 1–10, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. L. S. Marocchio, J. Lima, F. F. Sperandio, L. Corrêa, and S. O. M. de Sousa, “Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection,” Journal of Oral Science, vol. 52, no. 2, pp. 267–273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Massano, F. S. Regateiro, G. Januário, and A. Ferreira, “Oral squamous cell carcinoma: review of prognostic and predictive factors,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 102, no. 1, pp. 67–76, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Sambandam, S. Sakamuri, S. Balasubramanian, and A. Haque, “RANK Ligand Modulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells,” Journal of Cellular Biochemistry, vol. 117, no. 1, pp. 118–125, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. M. M. Ahmed, “Expression profile of apoptotic mediators and proliferative markers in oral squamous cell carcinoma,” Journal of the Egyptian National Cancer Institute, vol. 21, pp. 85–92, 2009. View at Google Scholar
  6. X. E. Liu, X. D. Sun, and J. M. Wu, “Expression and significance of VEGF-C and FLT-4 in gastric cancer,” World Journal of Gastroenterology, vol. 10, pp. 352–355, 2004. View at Google Scholar
  7. W. M. Tilakaratne, “Oral cavity and major and minor salivary glands,” in The Cancer Handbook, pp. 1–15, John Wiley Sons, 2nd edition, 2007. View at Google Scholar
  8. C. Norrmén, T. Tammela, T. V. Petrova, and K. Alitalo, “Biological basis of therapeutic lymphangiogenesis,” Circulation, vol. 123, no. 12, pp. 1335–1351, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Shintani, C. Li, T. Ishikawa, M. Mihara, K.-I. Nakashiro, and H. Hamakawa, “Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma,” Oral Oncology, vol. 40, no. 1, pp. 13–20, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Miyahara, J.-I. Tanuma, K. Sugihara, and I. Semba, “Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma,” Cancer, vol. 110, no. 6, pp. 1287–1294, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Alitalo and M. Detmar, “Interaction of tumor cells and lymphatic vessels in cancer progression,” Oncogene, vol. 31, no. 42, pp. 4499–4508, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Moussai, H. Mitsui, J. S. Pettersen et al., “The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C,” Journal of Investigative Dermatology, vol. 131, no. 1, pp. 229–236, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. N. E. Tobler and M. Detmar, “Tumor and lymph node lymphangiogenesis—impact on cancer metastasis,” Journal of Leukocyte Biology, vol. 80, no. 4, pp. 691–696, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Birke, E. Lütjen-Drecoll, D. Kerjaschki, and M. T. Birke, “Expression of podoplanin and other lymphatic markers in the human anterior eye segment,” Investigative Ophthalmology and Visual Science, vol. 51, no. 1, pp. 344–354, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Raica, A. M. Cimpean, and D. Ribatti, “The role of podoplanin in tumor progression and metastasis,” Anticancer Research, vol. 28, pp. 2997–3006, 2008. View at Google Scholar · View at Scopus
  16. Y. He, I. Rajantie, K. Pajusola et al., “Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels,” Cancer Research, vol. 65, no. 11, pp. 4739–4746, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. A. Stacker, M. E. Baldwin, and M. G. Achen, “The role of tumor lymphangiogenesis in metastatic spread,” FASEB Journal, vol. 16, no. 9, pp. 922–934, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. C. S. M. Williams, R. D. Leek, A. M. Robson et al., “Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer,” Journal of Pathology, vol. 200, no. 2, pp. 195–206, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Watanabe, M. Kato, I. Kotani, K. Ryoke, and K. Hayashi, “Lymphatic vessel density and vascular endothelial growth factor expression insquamous cell carcinomas of lip and oral cavity: a clinicopathological analysiswith immunohistochemistry using antibodies to D2-40, VEGF-C and VEGF-D,” Yonago Acta Medica, vol. 56, pp. 29–37, 2013. View at Google Scholar · View at Scopus
  20. S. Hirakawa, L. F. Brown, S. Kodama, K. Paavonen, K. Alitalo, and M. Detmar, “VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites,” Blood, vol. 109, no. 3, pp. 1010–1017, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Sugiura, Y. Inoue, R. Matsuki et al., “VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker,” International Journal of Oncology, vol. 34, no. 3, pp. 673–680, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Kono, M. Watanabe, H. Abukawa, O. Hasegawa, T. Satomi, and D. Chikazu, “Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma,” Journal of Oral and Maxillofacial Surgery, vol. 71, no. 10, pp. 1694–1702, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Yanase, K. Kato, K. Yoshizawa, N. Noguchi, H. Kitahara, and H. Nakamura, “Prognostic value of vascular endothelial growth factors A and C in oral squamous cell carcinoma,” Journal of Oral Pathology and Medicine, vol. 43, no. 7, pp. 514–520, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Audet, N. J. Beasley, C. MacMillan, D. G. Jackson, P. J. Gullane, and S. Kamel-Reid, “Lymphatic vessel density, nodal metastases, and prognosis in patients with head and neck cancer,” Archives of Otolaryngology - Head and Neck Surgery, vol. 131, no. 12, pp. 1065–1070, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Takizawa, K. Kondo, H. Fujino et al., “The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer,” British Journal of Cancer, vol. 95, no. 1, pp. 75–79, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Alitalo, “The lymphatic vasculature in disease,” Nature Medicine, vol. 17, no. 11, pp. 1371–1380, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Choi and J. N. Myers, “Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy,” Journal of Dental Research, vol. 87, no. 1, pp. 14–32, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. A. V. Benest, S. J. Harper, S. Y. Herttuala, K. Alitalo, and D. O. Bates, “VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis,” Cardiovascular Research, vol. 78, no. 2, pp. 315–323, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Cao, P. Linden, J. Farnebo et al., “Vascular endothelial growth factor C induces angiogenesis in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 24, pp. 14389–14394, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Cao, H. Jia, N. Fenga et al. et al., “Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis,” Proceedings of the National Academy of Sciences, vol. 109, no. 39, pp. 15894–15899, 2012. View at Publisher · View at Google Scholar
  31. T. Li, J. Yang, Q. Zhou, and Y. He, “Molecular Regulation of Lymphangiogenesis in Development and Tumor Microenvironment,” Cancer Microenvironment, pp. 1–12, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. J.-C. Chen, Y.-W. Chang, C.-C. Hong, Y.-H. Yu, and J.-L. Su, “The role of the VEGF-C/VEGFRs axis in tumor progression and therapy,” International Journal of Molecular Sciences, vol. 14, no. 1, pp. 88–107, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. S.-T. Vilen, T. Salo, T. Sorsa, and P. Nyberg, “Fluctuating roles of matrix metalloproteinase-9 in oral squamous cell carcinoma,” The Scientific World Journal, vol. 2013, Article ID 920595, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. X.-M. Yu, C.-Y. Lo, W.-F. Chan, K.-Y. Lam, P. Leung, and J. M. Luk, “Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases,” Clinical Cancer Research, vol. 11, no. 22, pp. 8063–8069, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Yamaguchi, H. Yano, O. Nakashima et al., “Expression of vascular endothelial growth factor-C in human hepatocellular carcinoma,” Journal of Gastroenterology and Hepatology (Australia), vol. 21, no. 1, pp. 152–160, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. X. Cai, S. Ma, M. Gu, C. Zu, W. Qu, and X. Zheng, “Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer,” Diagnostic Pathology, vol. 7, no. 1, article no. 52, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Ran, L. Volk, K. Hall, and M. J. Flister, “Lymphangiogenesis and lymphatic metastasis in breast cancer,” Pathophysiology, vol. 17, no. 4, pp. 229–251, 2010. View at Publisher · View at Google Scholar · View at Scopus