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| Study ID | Methods | Participants | Mean age (range), years | Interventions | Outcomes | Follow-up | Note |
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| Bottini, 2012 | Parallel design RCT where patients were randomly assigned to the two treatment groups | 40 (17F and 23M) | 22–80, mean (45–65) | Group 1: immediate implants were inserted in association with a deantigenated collagenated bone substitute of porcine origin and were maintained in place by the use of equine collagen sponge. Group 2: immediate implants were placed with no grafting material | The measurement of the buccolingual width, implant mobility, pain, suppuration, and peri-implant radiolucency | 6-month | Italy |
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| Cornelini, 2004 | Parallel design RCT where patients were randomly assigned to treatment groups | 20 (11F-9M) | 21–60, mean 45 | Group 1: immediate implants with Bio-Oss (bovine-derived porous bone mineral matrix) covered by Bio-Gide membrane (pure collagen membrane). Group 2: immediate implants with Bio-Gide membrane alone. | Proximal radiographic bone level, mucosal coverage of the implant, probing attachment level, oral hygiene status (plaque score) and soft tissue condition (mucositis score) | 6-month | Country not stated |
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| Daif, 2013 | Parallel design RCT where patients were randomly divided into two equal groups | 28 (18F and 10M) | 22–48, mean 34 | Group 1: immediate implants with pure-phase multiporous beta-TCP particles. Group 2: immediate implants with no filling materials | Bone density, implant failure, and infection | 3 and 6 months after loading (implant loading three months after surgery) | Egypt |
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| De Angelis, 2011 | Multicenter parallel group RCT. Four computer-generated restricted random lists were created | 80 | — | Group 1: immediate implant with the bone substitute granules (Endobon®; Biomet 3i) and a resorbable collagen barrier (OsseoGuard®, Biomet 3i). Group 2: immediate implants with a resorbable collagen barrier (OsseoGuard®, Biomet 3i) alone | Implant failures, any biological or biomechanical complications, peri-implant marginal bone levels, esthetic evaluation of the vestibular and occlusal clinical pictures, and patient satisfaction | 1 year after loading (implant loading after 3-4 months) | Italy |
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| Gher, 1994 | Factorial design RCT. The patients were randomly assigned to four treatment groups according to implant type and use or nonuse of DFDBA at the time of implant placement | 36 | — | Group 1: Titanium plasma-sprayed implant 3 without DFDBA. Group 2: Titanium plasma-sprayed implant with DFDBA. Group 3: Hydroxyapatite-coated implant 1 without DFDBA. Group 4: Hydroxyapatite-coated implant with DFDBA | Implant failure and crestal bone apposition measurements | 6-month | USA |
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| Prosper, 2003 | Parallel design RCT. The patients were divided randomly into 2 groups | 83 | 21–75 | Group 1: immediate implants in combination with the use of synthetic hydroxyapatite and patients. Group 2: immediate implants combined with a bioabsorbable membrane based on polyglycolic and polylactic acid copolymers | Soft-tissue examination, implant mobility, bone loss, and implant success | Every 3 months for an overall period of 4 years | Italy |
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