Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

Figure 1

Periodontitis (a) results based on PerioSafe®-mouth-rinse test: two chronic periodontitis patients (1) and (3) before and (2) and (4) after nonsurgical periodontal treatment, scaling, and root planning (SRP). The appearance of two lines (>20 ng/ml) pointed by arrows in the figure is a considered positive test which indicates elevated risk for periodontitis. The appearance of only one line indicates successful test performance and no risk for periodontitis (aMMP-8 < 20 ng/ml) after SRP treatment. Peri-implantitis (b) results based on ImplantSafe®-PISF-strip-test; two peri-implantitis patients (1) and (3) before and (2) and (4) after peri-implantitis treatment (plastic scaling, oral hygiene instructions, and use of chlorhexidine). Two lines in the result window indicate elevated aMMP-8 in PISF and increased risk for peri-implantitis. The appearance of a single line indicates successful test performance, low aMMP-8 in PISF, and no risk for peri-implantitis after treatment [78, 84].