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| Study | Pang et al. [19] | Temmerman et al. [20] |
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| Methods | Randomized controlled clinical trial | Randomized controlled clinical split mouth trial |
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| Participants | 60 patients | 22 patients |
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| Surgical considerations | Extraction with two vertical releasing incisions (mesial/distal) plus collagen membrane with DBB collagen sponge | Extraction plus 2-3 PRF |
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| Intervention | Test group: deproteinized collagen bovine bone covered with collagen membrane | Test group: leukocyte-platelet-rich fibrin |
| Control group: spontaneous healing | Control group: spontaneous healing |
| Level A buccal defects: between 3 and 5 mm | |
| Level B buccal defects: 5 mm or more | |
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| Measurement method | CBCT/ISQ | CBCT |
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| Follow-up | 6 months postoperatively | 3 months postoperatively |
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| Outcome | Vertical resorption: | Vertical resorption (lingual): |
| (i) Level A (control group): −2.92 ± 0.31 mm | −0.7 ± 0.8 mm (control group) |
| (ii) Level A (test group): −1.53 ± 0.26 mm | −0.3 ± 1.2 mm (L-PRF group) |
| (iii) Level B (control group): −3.17 ± 0.37 mm | Vertical resorption (buccal): |
| (iv) Level B (test group): −2.48 ± 0.22 mm | −1.6 ± 1.2 mm (control group) |
| | −0.1 ± 1.6 mm (L-PRF group) |
| Horizontal resorption: | Horizontal resorption (lingual): |
| (i) Level A (control group): −3.26 ± 0.44 mm | (Control group) |
| (ii) Level A (test group): −2.87 ± 0.25 mm | HW-1 mm: −2.0 ± 2.6 mm |
| (iii) Level B (control group): −3.82 ± 0.33 mm | HW-3 mm: −0.2 ± 0.3 mm |
| (iv) Level B (test group): −3.05 ± 0.18 mm | HW-5 mm: −0.1 ± 0.3 mm |
| | (Test group) |
| | HW-1 mm: −0.3 ± 1.9 mm |
| | HW-3 mm: −0.1 ± 0.3 mm |
| | HW-5 mm: −0.0 ± 0.1 mm |
| Mean ISQ test group: | Horizontal resorption (buccal): |
| Immediately after implant placement: 62.33–63.40 | (Control group) |
| 1 month postoperatively: 60 | HW-1 mm: −3.3 ± 2.6 mm |
| 3 months postoperatively: 72 | HW-3 mm: −1.0 ± 1.1 mm |
| | HW-5 mm: −0.5 ± 0.7 mm |
| Mean ISQ control group: | (Test group) |
| 1 month postoperatively:– | HW-1 mm: −1.2 ± 2.6 mm |
| 3 months postoperatively: 70 | HW-3 mm: −0.8 ± 0.9 mm |
| | HW-5 mm: −0.5 ± 0.6 mm |
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| Secondary outcome | Level B (control group): implants could not be placed in 3 patients | L-PRF group: 94.7% socket fill |
| Control group: 63.3% socket fill |
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