β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese
Table 2
Correlation of urine biological markers with microbiological/clinical parameters related to periodontitis.
NGAL/Cre ρ (P value)
β2-MG/Cre ρ (P value)
α1-MG/Cre ρ (P value)
Age (years)
0.235 (0.015)
0.086 (0.378)
0.137 (0.158)
Subgingival plaque (copy)
P. gingivalis
0.185 (0.055)
0.100 (0.305)
0.092 (0.344)
P. intermedia
–0.107 (0.271)
0.158 (0.102)
0.183 (0.057)
A. actinomycetemcomitans
–0.106 (0.273)
–0.040 (0.683)
–0.102 (0.296)
Total bacteria
0.043 (0.657)
0.111 (0.253)
0.160 (0.097)
Antibody titer (unit)
P. gingivalis
0.110 (0.255)
0.082 (0.400)
–0.012 (0.904)
P. intermedia
–0.015 (0.876)
0.021 (0.827)
–0.214 (0.026)
A. actinomycetemcomitans
–0.003 (0.972)
0.065 (0.505)
0.053 (0.588)
Parameters related to periodontitis
O’Leary’s PCR (%)
0.089 (0.362)
0.043 (0.659)
–0.054 (0.578)
BOP (%)
0.056 (0.564)
–0.006 (0.954)
–0.111 (0.251)
Mean PD (mm)
0.037 (0.706)
0.193 (0.045)
0.271 (0.005)
PD ≥ 4 mm (number of sites)
0.124 (0.201)
0.118 (0.223)
0.158 (0.102)
PD 4, 5 mm (number of sites)
0.091 (0.349)
0.119 (0.221)
0.171 (0.078)
PD ≥ 6 mm (number of sites)
0.211 (0.029)
0.126 (0.193)
0.105 (0.279)
Mean CAL (mm)
0.129 (0.182)
0.248 (0.010)
0.266 (0.005)
CAL ≥ 4 mm (number of sites)
0.214 (0.026)
0.182 (0.059)
0.184 (0.056)
CAL 4, 5 mm (number of sites)
0.193 (0.045)
0.193 (0.046)
0.192 (0.047)
CAL ≥ 6 mm (number of sites)
0.256 (0.007)
0.123 (0.205)
0.097 (0.317)
Spearman's rank correlation coefficient was performed for statistical analysis. The statistically significant values are indicated by ,. NGAL, neutrophil gelatinase-associated lipocalin; β2-MG, β2-microglobulin; α1-MG, α1-microglobulin; Cre, creatinine; P. gingivalis, Porphyromonas gingivalis; P. intermedia, Prevotella intermedia; A. actinomycetemcomitans, Aggregatibacter actinomycetemcomitans; O’Leary’s PCR, O’Leary’s plaque control record; BOP, bleeding on probing; PD, probing depth; CAL, clinical attachment level.
