Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus

Table 3

Estimated frequencies (%) of IL-1 haplotypes in patients with CP, T1DM (and T1DM + CP subgroup), T2DM (and T2DM + CP subgroup), and healthy controls.

IL-1A (−889C/T)	IL-1B (+3953C/T)	IL-1RN (VNTR)^§	Controls ()	CP ()	T1DM ()	T1DM + CP ()	T2DM ()	T2DM + CP ()
C	C	L	43.14	48.66	47.47	46.60	46.14	49.37
C	C	S	21.64	21.50	14.03	17.39	18.11	17.86
T	T	L	21.35	13.35	15.62	18.03	17.42	19.06
T	C	L	4.99	5.83	9.40	3.31	6.77	3.65
C	T	L	3.19	3.65	8.20	8.38	5.12	2.65
T	T	S	2.23	2.53	2.70	3.85	2.79	2.16
T	C	S	2.10	3.76	2.59	2.44	2.65	4.35
C	T	S	1.36	0.73	—	—	1.02	0.91

CP = chronic periodontitis; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus. ^§For haplotype analysis, alleles with more than two repeat units were grouped together as IL-1RNL (“long” allele) and 2 repeat units were marked as IL-1RNS (“short” allele). Haplotypes are ordered according to decreasing haplotype frequency in the healthy control subjects. in comparison to healthy controls (without correction for multiple comparisons).