Impact of Saliva and Cariogenic Microbiota on the Chemotherapy-Induced Oral Mucositis in Oncopediatric Patients: A Preliminary Longitudinal Study

Table 1

Inclusion and exclusion criteria.

---

Inclusion criteria:

 General

  Age between 4 and 18 years

  Diagnosis of primary malignant neoplasm

  No uncontrolled motor and psychological disturbances

  Not having started chemotherapy

  Only present chemotherapy only as a treatment in the first month

  Perform all treatments in the Napoleão Laureano Hospital

 Local

  Healthy oral mucosa

  Ability to spit saliva

Exclusion criteria

 Lesions of the oral mucosa before the chemotherapy

 Local irradiation history (head and neck)

 Inadequate oral hygiene

 Children who can not spit saliva

 Termination or transfer of treatment to another hospital within 70 days

 Terminal critical patients

 Presence of xerostomia (baseline)

 Patients with restarted treatment for recurrent neoplasia

 Non-collaborative patients

---