Polymodal Activation and Desensitization of TRPV1 Receptor in Human Odontoblasts-Like Cells with Eugenol

<div>Calculation of EUG and CAP EC50 in hOLCs using resazurin technique. The EC50 was calculated from the resazurin assay in hOLCs exposed to different concentrations of the two compounds. (a) EUG EC50. Concentration range: 10, 5, 1, 0.5, and 0.1 mM. LogEC50 : 2.781, equivalent to 603.5 <i>μ</i>M. (b) CAP EC50. Concentration range: 50, 10, 5, 1, and 0.5 mM. LogEC50 : 1.004, equivalent to 10.1 <i>μ</i>M. GraphPad Prism 7.00 software was used. The curves represent the results of 3 independent experiments with six replicates each (<i>n</i> = 18).</div>

International Journal of Dentistry

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Figure 5

Figure 5: Polymodal Activation and Desensitization of TRPV1 Receptor in Human Odontoblasts-Like Cells with Eugenol 