Clinical Effects of Mercury in Conservative Dentistry: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials

Table 3

GRADE summary of findings for meta-analysis on urinary mercury concentration after 5 years of exposure to dental amalgam or composite resin in children.

Quality assessment and outcome: urinary mercury levels after 5 years of exposure to dental amalgam or composite resin in children
Question: Will the use of dental amalgam for restoring dental caries in children produce an increase in urinary mercury levels?
Number of studies according to meta-analysis	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Publication bias
2	Clinical controlled Trials	Serious^a	Serious^b	Not serious	Not serious	Undetected

^aDue to high risk of bias in one included trial. ^bDue to heterogeneity across studies.