HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma

Figure 1

Immunomarking for HIF-1α, p53, Bax, and BNIP3 in AMB and FP. HIF-1α staining in AMB (a) was nuclear in the solid tumour area (arrowheads) and cytoplasmic and nuclear in cells near the cystic areas of the epithelial islets (arrow and cystic lumen,). p53 immunostaining in AMB (c) is predominant in the nucleus and cytoplasm of cells close to the cystic areas (cystic lumen,) of epithelial islands (arrow). Staining is also detected in selected cells from the basal layer (c) (arrowhead). Bax immunostaining in AMB (e) is predominant in the cytoplasm of cells close to the cystic areas of epithelial islands (arrow). BNIP3 immunostaining in AMB (g) is predominant in the cytoplasm of cells close to the cystic areas of epithelial islands. Marking is also detected in selected cells from the basal and central layers (arrowhead and arrow, resp.). The FP shows a weaker labelling of the HIF-1α, p53, Bax, and BNIP3 proteins compared with AMB (b, d, f, h). Scale 100 and 20 μm. Comparison of immunoexpression of the p53, Bax, and BNIP3) and HIF-1α in the ameloblastoma (a) and the follicle dental (f). (m).

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