HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma

Figure 2

Immunomarking for HIF-1α, IAP-2, GLUT1, and Bcl-2 in AMB and FP. HIF-1α staining in AMB (a) was nuclear in the solid tumour area (arrowheads) and cytoplasmic and nuclear in cells near the cystic areas of the epithelial islets (arrow and cystic lumen, ). IAP-2 labelling on AMB (c) was predominant in the cytoplasm and nucleus (arrow) of the cells of the epithelial islands. Marking is also detected in selected cells from the basal and central layers (arrowhead and arrow, resp.). GLUT1 immunostaining in AMB (e) is predominant in the cytoplasm of the cells of the basal and central layer of the epithelial islands (arrowhead and arrow, resp.). Bcl-2 immunostaining in AMB (g) is predominant in the cytoplasm of epithelial island cells (arrow). Marking is also detected in selected cells from the basal and central layers (arrowhead and arrow, resp.). The FP shows a weaker labelling of the proteins IAP-2, GLUT1, and Bcl-2 compared with AMB (b, d, f, h). Scale 100 and 20 μm. Comparison of immunoexpression of the HIF-1α, IAP-2, GLUT1 and Bcl-2, and HIF-1α in the ameloblastoma (a) and the follicle dental (f). (m).

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