HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma

Figure 3

Protein-protein interaction network for HIF-1α, GLUT1 (SLC2A1), TP53, and LDHA genes obtained through the STRING platform. It is noteworthy that all interactions observed between proteins (edges connecting the nodes) were experimentally characterized (pink line) and obtained from cured databases (light blue line). The other interactions observed: HIF-1α and GLUT1 (SLC2A1); HIF-1α and TP53; HIF-1 and LDHA; GLUT1 (SLC2A1) and TP53; GLUT1 (SLC2A1) and LDHA; LDHA and TP53 presented confirmations based on analysis of text mining (yellow line) and coexpression (black line) observed computationally from transcript-transcript interactions.