HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma

Figure 4

Schematic representation of hypoxia-induced proapoptotic and antiapoptotic signalling pathways. The involvement of HIF-1α is described in these pathways. The solid lines indicate a direct interaction; the dashed line indicates an indirect interaction. Induction (arrow); inhibition (headless arrow). APAF-1, cytochrome C, and procaspase 9 form the apoptosome that activates caspase 9. APAF-1: apoptotic protease activating factor 1; BNIP3: protein 3 that interacts with BCL-2/adenovirus E1B of 19 kDa; HIF-1α: hypoxia-inducible factor 1; IAP-2: inhibitor of apoptosis protein 2; GLUT1: glucose transporter; MOMP: mitochondrial outer membrane permeabilisation; caspase 9 (inducer); caspases 3 (irreversible apoptosis marker); caspase 7 (effector). By Katherine J. Palma Valladares withhttps://app.biorender.com/.