Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

Table 2

Mean and standard deviation of each histological variable in the four groups (mm²).

Group	Number of Howship’s lacunae		Number of blood vessels		Number of osteoclasts		Number of root resorption lacunae
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Negative control	0.16	0.40	1.66	0.81	0.83	0.40	0.00	0.00
Positive control	2.00	0.89	3.50	1.04	2.16	0.75	0.83	0.40
Methotrexate 0.75 mg/kg	2.83	0.75	5.50	1.04	3.00	0.89	1.16	0.40
Methotrexate 1.5 mg/kg	3.16	1.47	7.33	1.21	4.33	0.81	1.33	0.51
value‡	<0.001		<0.001		<0.001		<0.001

‡One-way ANOVA test followed by Tukey’s test was used. Means with same superscript letters are not significantly different ().