Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial

Table 1

Mean and standard deviation values for inter- and intragroup comparisons in all clinical variables between test and control sites.

	Test site (melatonin gel), n = 24	Control site (placebo gel), n = 24	value
Plaque Index (PI)
Baseline	2 ± 0.7	1.96 ± 0.6	0.83
Posttreatment	0.7 ± 0.6	0.7 ± 0.6	0.83
value	<0.0001	<0.0001
Gingival Index (GI)
Baseline	2.5 ± 0.5	2.4 ± 0.5	0.5
Posttreatment	0.6 ± 0.5	0.7 ± 0.5	0.5
value	<0.001	<0.001
Probing depth (PD)
Baseline	4.3 ± 0.8	4.0 ± 0.6	0.1485
Posttreatment	2.9 ± 0.7	3.1 ± 0.7	0.3275
value	<0.001	<0.001
Clinical attachment level (CAL)
Baseline	4.7 ± 0.9	4.3 ± 0.6	0.07
Posttreatment	3.5 ± 0.6	3.7 ± 0.6	0.254
value	<0.001	<0.001