Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial

Table 2

Mean and standard deviation values for comparing % changes in all clinical variables among test and control sites.

Clinical parameters	Test site (melatonin gel), n = 24	Control site (placebo gel), n = 24	value
Plaque Index (PI)
Baseline	2 ± 0.7	1.96 ± 0.6	0.83
Posttreatment	0.7 ± 0.6	0.7 ± 0.6	0.83
% change	−65%	−64.29%	<0.001
Gingival Index (GI)
Baseline	2.5 ± 0.5	2.4 ± 0.5	0.5
Posttreatment	0.6 ± 0.5	0.7 ± 0.5	0.5
% change	−80%	−70.83%	<0.001
Probing depth (PD)
Baseline	4.3 ± 0.8	4.0 ± 0.6	0.1485
Posttreatment	2.9 ± 0.7	3.1 ± 0.7	0.3275
% change	−32.56%	−22.5%	<0.001
Clinical attachment level (CAL)
Baseline	4.7 ± 0.9	4.3 ± 0.6	0.07
Posttreatment	3.5 ± 0.6	3.7 ± 0.6	0.254
% change	−25.53%	−13.95%	<0.001