The Role of Oral Fusobacterium nucleatum in Female Breast Cancer: A Systematic Review and Meta-Analysis

Table 2

Overall data from AXIS tool conducted studies . Calculated relative risk (RR), 95% CI and values investigating the efficacy of FN from the oral microbiome and its biomarker potential for breast cancer in adult women.

Type of analysis	No. of studies	Heterogeneity		Results
			I^2(%)	RR	95% CI	value
Overall analysis (articles included from AXIS tool analysis only)	6	0.03	50.89	1.28	1.03–1.45	<0.01
Study design
Prospective cohort	4	0.08	43.24	1.18	0.95–1.40	0.07
Retrospective cohort	1	0.35	40.65	1.22	1.11–1.39	<0.01
Case-control	1	—	—	2.10	1.15–2.78	0.04
Follow-up period
<10 years	3	0.55	0.73	1.18	1.15–1.29	<0.01
≥10 years	2	0.05	65.94	1.41	0.88–1.87	0.06
Dental status
PD	6	0.04	51.74	1.24	1.01–1.30	0.04

CASP-Tool examined articles were omitted due to insufficient statistical data. 1 Article omitted due to absence of follow-up period.