The Role of Oral Fusobacterium nucleatum in Female Breast Cancer: A Systematic Review and Meta-Analysis
Table 2
Overall data from AXIS tool conducted studies . Calculated relative risk (RR), 95% CI and values investigating the efficacy of FN from the oral microbiome and its biomarker potential for breast cancer in adult women.
Type of analysis
No. of studies
Heterogeneity
Results
I2(%)
RR
95% CI
value
Overall analysis (articles included from AXIS tool analysis only)
6
0.03
50.89
1.28
1.03–1.45
<0.01
Study design
Prospective cohort
4
0.08
43.24
1.18
0.95–1.40
0.07
Retrospective cohort
1
0.35
40.65
1.22
1.11–1.39
<0.01
Case-control
1
—
—
2.10
1.15–2.78
0.04
Follow-up period
<10 years
3
0.55
0.73
1.18
1.15–1.29
<0.01
≥10 years
2
0.05
65.94
1.41
0.88–1.87
0.06
Dental status
PD
6
0.04
51.74
1.24
1.01–1.30
0.04
CASP-Tool examined articles were omitted due to insufficient statistical data. 1 Article omitted due to absence of follow-up period.