Vitamin D Supplementation for Prevention of Dental Implant Failure: A Systematic Review
Table 3
Data from animal studies.
Author
Title
Study type
Results
Kelly et al., 2008
Vitamin D and bone physiology: Demonstration of vitamin D deficiency in an implant osseointegration rat model
Animal study
Exposed implant surface in vitamin D-deficient rats
Zhou et al., 2012
1,25-Dihydroxy vitamin D3 improves titanium implant osseointegration in osteoporotic rats
Animal study
Increased bone density by 1.2-fold, osseointegration by 1.5-fold, and extrusion force resistance by 2.0-fold in osteoporotic rats. The trabecular bone amount was elevated by 96%, and osseointegration was elevated up to 94.4%. Trabecular number was elevated by 112.5% and 51.8% connective tissue
Wu et al., 2012
Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats
Animal study
Bone volume, osseointegration, trabecular bone number and thickness, connective tissue density, BIC, and push-out force were improved
Akhavan et al., 2012
The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats
Animal study
No significant effect of vitamin D on osseointegration in diabetic rats
Dvorak et al., 2012
Impact of dietary vitamin D on osseointegration in the ovariectomized rat
Animal study
No significant rescission of the BIC in the medullar and periosteal compartment among rats that received vitamin D when compared to those that did not
Liu et al., 2014
Vitamin D supplementation enhances the fixation of titanium implants in CKD mice
Animal study
A significant difference was observed when vitamin D supplements were given to rats with CKD