Review Article
Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review
Table 1
Prognostic difference between HPV(+) and HPV(−) HNSCC.
| | HPV(+) | HPV(−) |
| Mutational load | Lower | Higher | Cell differentiation | Low | Marked | 5-year survival rate | 75–80% | <50% | Biomarkers | Overexpression of P16, inactivation of p53 | Loss of P16, p53 mutation | Metastasis | Infrequent | Frequent | Radiosensitive/chemosensitive | +++ | + |
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