Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review

Table 1

Prognostic difference between HPV(+) and HPV(−) HNSCC.

	HPV(+)	HPV(−)
Mutational load	Lower	Higher
Cell differentiation	Low	Marked
5-year survival rate	75–80%	<50%
Biomarkers	Overexpression of P16, inactivation of p53	Loss of P16, p53 mutation
Metastasis	Infrequent	Frequent
Radiosensitive/chemosensitive	+++	+