Research Article

Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin V in Osteoclasts Cultured In Vitro

Figure 4

Comparison of cathepsin K expression in cultured osteoclasts stimulated in vitro with alendronate (95.4 mM) or risedronate (95.4 mM) with that in control cells. Significant downregulation of cathepsin K at 48 and 72 h with alendronate and at 48 h with risedronate; and . The plot shows flow cytometry staining data.