Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection

Table 1

Parameters, their symbols, and default values used in Model (3).

Parameters	Meaning	Value	References
	Maximum hepatocyte growth rate	≤1.0 day^−1	[23, 24]
	Hepatocyte carrying capacity	2 × 10^11 cells	[25]
	Rate of virion infection of hepatocytes	3.6 × 10^−5–1.8 × 10^−3 cells virion^−1 day^−1	[26]
	Time delay	1 day	[27, 28]
	Normal death rate for hepatocytes	.0039 day^−1	[27, 28]
	Infected hepatocyte death rate	0.0693–0.00693 day^−1	[25]
	Clearance rate of infection	7 ± 1.7 × 10^−4 ml/cell day^−1	[29]
	Number of free viruses produced by infected cells	480	[12, 13]
	Free virion half-life	0.67 day^−1	[30]
	Neutralization rate of virion and antibodies	10^−10–10^−12 ml day^−1	[31]
	Activation rate of B-cells	1.38 × 10^−2–10^−4 day^−1	[31]
	Death rate of B-cells	0.03–0.1 day^−1	[31]
	Activation rate of CTL cells	4.4 ± 1.5 × 10^−7 ml cell^−1 day^−1	[29]
	Death rate of CTL cells	0.5 day^−1	[32]