Prolactin and Male Fertility: The Long and Short Feedback Regulation

Table 3

Effects of estradiol 17β on serum hormones in adult male rat.

Estradiol 17β	Plasma levels (ng/mL)
(μg/kg/d)	LH	FSH	PRL	T
0	0.85±0.09	6.16±0.32	122.37±6.17	2.17±0.31
0.1	0.89±0.108	5.58±0.498	115.80±4.03	1.50±0.17
10	0.54±0.109^*	3.49±0.38^*	120.60±4.70	1.44±0.19
100	0.43±0.09^*	2.38±0.24^*	255.50±17.9^*	0.72±0.04^*
200	0.31±0.08^*	2.67±0.17^*	306.00±22.27^*	0.84±0.09^*
300	0.19±0.05^*	2.65±0.13^*	370.00±13.60^*	0.89±0.06^*
400	0.17±0.03^*	2.48±0.56^*	364.30±38.07^*	0.83±0.10^*
1000	0.36±0.096^*	2.98±0.18^*	465.00±51.19^*	0.63±0.097^*

Estradiol 17β was dissolved in saline by sonication and injected s.c. Male rats were mated at 60 days of treatment and serum hormones analyzed by RIA. All values are expressed as mean ± SEM. Dose “0” represents control values. ^*denotes significance at 𝑃≤0.5 as compared to controls [59].