International Journal of Endocrinology

Review Article

Prolactin and Male Fertility: The Long and Short Feedback Regulation

Table 4

Effects of fluphenazine decanoate on fertility parameters and serum hormones in adult male rat.
Affected Fluphenazine treatment (mg/kg/d) for 60 days
parameters0123
Prolactin, ng/ml 1 8 . 9 9 ± 1 . 8 2 7 6 . 8 0 ± 1 1 . 1 * 8 2 . 5 3 ± 1 0 . 6 * 1 3 9 . 3 0 ± 2 5 . 1 *
LH, ng/ml 1 . 1 3 ± 0 . 2 6 0 . 2 3 ± 0 . 0 4 * 0 . 4 4 ± 0 . 0 5 * 0 . 5 4 ± 0 . 0 5 *
FSH, ng/ml 7 . 7 2 ± 0 . 2 6 5 . 4 3 ± 0 . 4 4 * 6 . 0 8 ± 0 . 3 1 * 6 . 0 0 ± 0 . 2 2 *
Testosterone, ng/ml 2 . 6 0 ± 0 . 1 4 2 . 1 7 ± 0 . 1 7 2 . 4 0 ± 0 . 2 0 2 . 3 2 ± 0 . 2 4
Estradiol, ng/ml 8 2 . 0 0 ± 9 . 5 1 1 1 4 . 2 ± 2 1 . 3 7 0 . 6 1 ± 8 . 1 4 5 8 . 1 9 ± 1 0 . 4
Sperm count, million/cauda 6 3 . 8 ± 3 . 8 9 5 4 . 3 ± 4 . 1 8 5 2 . 8 ± 3 . 5 3 5 9 ± 6 . 6 8
Potency, % 1 0 0 ± 0 0 8 3 . 3 ± 1 1 . 2 4 1 0 0 ± 0 0 6 6 . 7 ± 1 4 . 2 1 *
Fecundity, % 1 0 0 ± 0 0 6 6 . 7 ± 2 1 . 0 9 8 3 . 3 ± 1 6 . 6 7 5 0 ± 2 2 . 3 6
Implantation sites, per rat 1 1 . 3 ± 1 . 1 6 6 . 7 ± 1 . 6 7 5 . 1 ± 1 . 5 4 * 5 . 4 ± 1 . 6 9 *
Litters sired, per female 1 0 . 3 ± 1 . 1 7 6 . 4 ± 1 . 6 4 . 8 ± 1 . 4 9 * 5 . 7 ± 1 . 7 3 *
Fertility index, per rat 0 . 9 ± 0 . 0 8 0 . 6 ± 0 . 1 4 0 . 5 ± 0 . 1 5 * 0 . 5 ± 0 . 1 5 *
Fluphenazine was dissolved in sesame oil and injected s.c. Male rats were mated at 60 days of treatment and serum hormones analyzed by RIA. Uterine horns of mated females were exposed to count implantation sites, ovaries for corpora lutea. All values are expressed as mean ± SEM. Dose “0” represents control values. *denotes significance at 𝑃 ≤ . 0 5 as compared to controls. Potency = % mated females; fecundity = % male rats siring at least one viable pup; fertility index = ratio of implantation sites to corpora lutea; litter size = number of pups per female [68].