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International Journal of Endocrinology
Volume 2009 (2009), Article ID 931057, 3 pages
http://dx.doi.org/10.1155/2009/931057
Case Report

Ectopic Calcification as Discernible Manifestation in Neonates with Pseudohypoparathyroidism Type 1a

1Department of Endocrinology & Metabolism, Clinical Research Institute, Kanagawa Children's Medical Center, Yokohama 232-8555, Japan
2Department of Pediatrics, Matsuyama Red Cross Hospital, Matsuyama 790-8524, Japan
3Department of Pediatrics, Yokohama Municipal Citizen's Hospital, Yokohama 240-8555, Japan
4Department of Pediatrics, Medical School Keio University, Tokyo 160-8582, Japan

Received 23 October 2008; Accepted 9 June 2009

Academic Editor: Maria I. New

Copyright © 2009 Masanori Adachi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The diagnosis of pseudohypoparathyroidism type 1a (PHP1a) is challenging, because both the osteodystrophy, such as brachydactyly and round face, and the symptomatic hypocalcemia usually develop beyond infancy. Although ectopic calcification may be an early sign of PHP1a, there are no systematic reviews regarding the time of its appearance. We here report on two PHP1a patients who presented with subcutaneous calcification in neonatal period.