Table 2: Sugar transporters and their expression in cancer.

TransporterTissuesRoles and properties

SGLT transporters

SGLT1Small intestine, kidney.Intestinal absorption of glucose from meal. Renal reabsorption of glucose.
SGLT2Kidney.Renal absorption of glucose from glomerular filtrate.

Class I GLUT transporters

GLUT1Erythrocytes, brain (blood-brain barrier).Basal glucose uptake.
GLUT2Liver, pancreatic islet cells, small intestine, kidney.Glucose sensing in pancreatic β-cells. Trans-epithelial glucose and fructose transport. High-capacity, low-affinity glucose transporter.
GLUT3Brain (neuronal), testis.Glucose neural transporter.
GLUT4Muscle, heart, adipose tissue.Expressed in tissues with insulin-stimulated acute glucose transport. In response to insulin, it is translocated to plasma membrane.

Class II GLUT transporters

GLUT5Small intestine, testis, muscle.Only fructose transporter.
GLUT7Intestine, testis, prostate.
GLUT9Liver, kidney.
GLUT11Heart, adipose tissue, kidney, placenta, muscle.GLUT11 has three isoforms: GLUT11a, GLUT11b, and GLUT11c, with distinct tissue distribution.

Class III GLUT transporters

GLUT6Brain, spleen, leukocytes.
GLUT8Brain, testis, adipocytes.
GLUT10Heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney.Mutations in GLUT10 were associated with arterial tortuosity syndrome. GLUT10 deficiency is associated with the upregulation of TGFB pathway in Loeys-Dietz syndrome.
GLUT12Placenta, adipose tissue, small intestine and skeletal muscle.In skeletal muscle, it is translocated to plasma membrane in response to insulin, like GLUT4.
HMITBrain.Myoinositol transporter.