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International Journal of Endocrinology
Volume 2010 (2010), Article ID 452820, 8 pages
Research Article

Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

1Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, Fukuoka 814-0180, Japan
2Department of Preventive Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
3Laboratory of Physical Science Inc., Fukuoka 810-0001, Japan
4Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan

Received 30 March 2010; Revised 6 July 2010; Accepted 2 September 2010

Academic Editor: Shunichi Shimasaki

Copyright © 2010 Yuichiro Nishida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels.