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International Journal of Endocrinology
Volume 2010, Article ID 481326, 6 pages
Research Article

An Innovative Mathematical Model: A Key to the Riddle of H b A 1 c

Division of Endocrinology and Metabolism, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad 9195977178, Iran

Received 8 February 2010; Accepted 13 June 2010

Academic Editor: Robert R. Henry

Copyright © 2010 Mahdi Kahrom. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


H b A 1 c is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the H b A 1 c test offers an overview of how well glucose has been controlled over the past 4 months. I devised an innovative mathematical model to describe novel equations governing H b A 1 c which enables analysis of H b A 1 c behavior and provides emerging new concepts in assessment of diabetes management. Linear relationship of H b A 1 c and mean plasma glucose along with the kinetic analysis of H b A 1 c formation has been used as the basic suppositions to construct this model. The main application of this devised model is prediction of mean plasma glucose at any desired point in time after a change in therapy and with great certainty. This model also appraises the pattern of H b A 1 c changes over time and provides a unique opportunity to address common mistakes and misconceptions in routine application of H b A 1 c that could have potentially important implications on diabetes control.