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International Journal of Endocrinology
Volume 2010 (2010), Article ID 579640, 11 pages
http://dx.doi.org/10.1155/2010/579640
Review Article

Does Vitamin D Deficiency Cause Hypertension? Current Evidence from Clinical Studies and Potential Mechanisms

1Division of General Internal Medicine and Hypertension, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
2Division of Endocrinology, University of Mississippi Medical Center, Jackson, MS 39216, USA
3Department of Medicine, G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS 39216, USA

Received 30 April 2009; Revised 26 July 2009; Accepted 29 August 2009

Academic Editor: Vin Tangpricha

Copyright © 2010 M. Iftekhar Ullah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. S. Calvo, S. J. Whiting, and C. N. Barton, “Vitamin D intake: a global perspective of current status,” The Journal of Nutrition, vol. 135, no. 2, pp. 310–316, 2005. View at Google Scholar
  2. S. E. Judd and V. Tangpricha, “Vitamin D deficiency and risk for cardiovascular disease,” The American Journal of the Medical Sciences, vol. 338, no. 1, pp. 40–44, 2009. View at Publisher · View at Google Scholar · View at PubMed
  3. M. F. Holick, “Medical progress: vitamin D deficiency,” The New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007. View at Publisher · View at Google Scholar · View at PubMed
  4. B. G. Druss, S. C. Marcus, M. Olfson, T. Tanielian, L. Elinson, and H. A. Pincus, “Comparing the national economic burden of five chronic conditions,” Health Affairs, vol. 20, no. 6, pp. 233–241, 2001. View at Publisher · View at Google Scholar
  5. T. L. Clemens, J. S. Adams, S. L. Henderson, and M. F. Holick, “Increased skin pigment reduces the capacity of skin to synthesise vitamin D3,” The Lancet, vol. 1, no. 8263, pp. 74–76, 1982. View at Google Scholar
  6. H. F. DeLuca, “Overview of general physiologic features and functions of vitamin D,” The American Journal of Clinical Nutrition, vol. 80, no. 6, pp. 1689S–1696S, 2004. View at Google Scholar
  7. M. F. Holick and M. Garabedian, “Vitamin D: photobiology, metabolism((30)), mechanism of action, and clinical applications,” in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, M. J. Favus, Ed., vol. 4, pp. 129–137, American Society for Bone and Mineral Research, Washington, DC, USA, 6th edition, 2006. View at Google Scholar
  8. M. F. Holick, “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease,” The American Journal of Clinical Nutrition, vol. 80, no. 6, pp. 1678S–1688S, 2004. View at Google Scholar
  9. M. F. Holick, “Vitamin D: a millennium perspective,” Journal of Cellular Biochemistry, vol. 88, pp. 296–307, 2003. View at Google Scholar
  10. Y. C. Li, G. Qiao, M. Uskokovic, W. Xiang, W. Zheng, and J. Kong, “Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure,” Journal of Steroid Biochemistry and Molecular Biology, vol. 89-90, pp. 387–392, 2004. View at Publisher · View at Google Scholar · View at PubMed
  11. Y. C. Li, J. Kong, M. Wei, Z.-F. Chen, S. Q. Liu, and L.-P. Cao, “1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system,” The Journal of Clinical Investigation, vol. 110, no. 2, pp. 229–238, 2002. View at Publisher · View at Google Scholar
  12. Intersalt Cooperative Research Group, “Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion,” British Medical Journal, vol. 297, no. 6644, pp. 319–328, 1988. View at Google Scholar
  13. S. G. Rostand, “Ultraviolet light may contribute to geographic and racial blood pressure differences,” Hypertension, vol. 30, no. 2, pp. 150–156, 1997. View at Google Scholar
  14. Z. Lu, T. C. Chen, L. Kline et al., “Photosynthesis of previtamin D1 in cities around the world,” in Proceedings of the Biologic Effects of Light Symposium, M. F. Holick and A. Kligman, Eds., pp. 48–52, Walter de Gruyter, Berlin, Germany, 1992.
  15. M. F. Holick, “McCollum award lecture, 1994: vitamin D—new horizons for the 21st century,” The American Journal of Clinical Nutrition, vol. 60, no. 4, pp. 619–630, 1994. View at Google Scholar
  16. M. F. Holick, “High prevalence of vitamin D inadequacy and implications for health,” Mayo Clinic Proceedings, vol. 81, no. 3, pp. 353–373, 2006. View at Publisher · View at Google Scholar
  17. D. A. McCarron, P. A. Pingree, R. J. Rubin, S. M. Gaucher, M. Molitch, and S. Krutzik, “Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak,” Hypertension, vol. 2, no. 2, pp. 162–168, 1980. View at Google Scholar
  18. R. Cooper and C. Rotimi, “Hypertension in populations of West African origin: is there a genetic predisposition?” Journal of Hypertension, vol. 12, no. 3, pp. 215–227, 1994. View at Google Scholar
  19. H. G. Langford and R. L. Watson, “Potassium and calcium intake, excretion, and homeostasis in blacks, and their relation to blood pressure,” Cardiovascular Drugs and Therapy, vol. 4, supplement 2, pp. 403–406, 1990. View at Google Scholar
  20. M. B. Zemel, P. C. Zemel, R. J. Bryg, and J. R. Sowers, “Dietary calcium induces regression of left ventricular hypertrophy in hypertensive non—insulin-dependent diabetic blacks,” American Journal of Hypertension, vol. 3, no. 6, pp. 458–463, 1990. View at Google Scholar
  21. M. B. Zemel, S. M. Gualdoni, and J. R. Sowers, “Reductions in total and extracellular water associated with calcium-induced natriuresis and the antihypertensive effect of calcium in blacks,” American Journal of Hypertension, vol. 1, no. 1, pp. 70–72, 1988. View at Google Scholar
  22. L. E. Griffith, G. H. Guyatt, R. J. Cook, H. C. Bucher, and D. J. Cook, “The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials,” American Journal of Hypertension, vol. 12, no. 1, pp. 84–92, 1999. View at Publisher · View at Google Scholar
  23. P. S. Allender, J. A. Cutler, D. Follmann, F. P. Cappuccio, J. Pryer, and P. Elliott, “Dietary calcium and blood pressure: a meta-analysis of randomized clinical trials,” Annals of Internal Medicine, vol. 124, no. 9, pp. 825–831, 1996. View at Google Scholar
  24. R. Scragg, M. Sowers, and C. Bell, “Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey,” American Journal of Hypertension, vol. 20, no. 7, pp. 713–719, 2007. View at Publisher · View at Google Scholar · View at PubMed
  25. S. E. Judd, M. S. Nanes, T. R. Ziegler, P. W. F. Wilson, and V. Tangpricha, “Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the Third National Health and Nutrition Examination Survey,” The American Journal of Clinical Nutrition, vol. 87, no. 1, pp. 136–141, 2008. View at Google Scholar
  26. D. Martins, M. Wolf, D. Pan et al., “Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey,” Archives of Internal Medicine, vol. 167, no. 11, pp. 1159–1165, 2007. View at Publisher · View at Google Scholar · View at PubMed
  27. J. P. Forman, E. Giovannucci, M. D. Holmes et al., “Plasma 25-hydroxyvitamin D levels and risk of incident hypertension,” Hypertension, vol. 49, no. 5, pp. 1063–1069, 2007. View at Publisher · View at Google Scholar · View at PubMed
  28. R. Krause, M. Buhring, W. Hopfenmuller, M. F. Holick, and A. M. Sharma, “Ultraviolet B and blood pressure,” The Lancet, vol. 352, no. 9129, pp. 709–710, 1998. View at Google Scholar
  29. M. Pfeifer, B. Begerow, H. W. Minne, D. Nachtigall, and C. Hansen, “Effects of a short-term vitamin D3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women,” The Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 4, pp. 1633–1637, 2001. View at Publisher · View at Google Scholar
  30. J. P. Forman, H. A. Bischoff-Ferrari, W. C. Willett, M. J. Stampfer, and G. C. Curhan, “Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies,” Hypertension, vol. 46, no. 4, pp. 676–682, 2005. View at Publisher · View at Google Scholar · View at PubMed
  31. K. L. Margolis, R. M. Ray, L. Van Horn et al., “Effect of calcium and vitamin D supplementation on blood pressure: the women's health initiative randomized trial,” Hypertension, vol. 52, no. 5, pp. 847–855, 2008. View at Publisher · View at Google Scholar · View at PubMed
  32. E. S. Orwoll and S. Oviatt, “Relationship of mineral metabolism and long-term calcium and cholecalciferol supplementation to blood pressure in normotensive men,” The American Journal of Clinical Nutrition, vol. 52, no. 4, pp. 717–721, 1990. View at Google Scholar
  33. R. Scragg, K.-T. Khaw, and S. Murphy, “Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults,” European Journal of Clinical Nutrition, vol. 49, no. 9, pp. 640–646, 1995. View at Google Scholar
  34. M. B. Snijder, P. Lips, J. C. Seidell et al., “Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women,” Journal of Internal Medicine, vol. 261, no. 6, pp. 558–565, 2007. View at Publisher · View at Google Scholar · View at PubMed
  35. B. Hintzpeter, G. B. M. Mensink, W. Thierfelder, M. J. Müller, and C. Scheidt-Nave, “Vitamin D status and health correlates among German adults,” European Journal of Clinical Nutrition, vol. 62, no. 9, pp. 1079–1089, 2008. View at Publisher · View at Google Scholar · View at PubMed
  36. J. M. Geleijnse, “Vitamin D and hypertension: does the women's health initiative solve the question?” Hypertension, vol. 52, no. 5, pp. 803–804, 2008. View at Publisher · View at Google Scholar · View at PubMed
  37. J. M. Lappe, D. Travers-Gustafson, K. M. Davies, R. R. Recker, and R. P. Heaney, “Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial,” The American Journal of Clinical Nutrition, vol. 85, no. 6, pp. 1586–1591, 2007. View at Google Scholar
  38. J. MacLaughlin and M. F. Holick, “Aging decreases the capacity of human skin to produce vitamin D3,” The Journal of Clinical Investigation, vol. 76, no. 4, pp. 1536–1538, 1985. View at Google Scholar
  39. L. M. Bodnar, H. N. Simhan, R. W. Powers, M. P. Frank, E. Cooperstein, and J. M. Roberts, “High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates,” The Journal of Nutrition, vol. 137, no. 2, pp. 447–452, 2007. View at Google Scholar
  40. B. Eskenazi, L. Fenster, and S. Sidney, “A multivariate analysis of risk factors for preeclampsia,” The Journal of the American Medical Association, vol. 266, no. 2, pp. 237–241, 1991. View at Publisher · View at Google Scholar
  41. E. Hyppönen, A.-L. Hartikainen, U. Sovio, M.-R. Järvelin, and A. Pouta, “Does vitamin D supplementation in infancy reduce the risk of pre-eclampsia?” European Journal of Clinical Nutrition, vol. 61, no. 9, pp. 1136–1139, 2007. View at Publisher · View at Google Scholar · View at PubMed
  42. L. M. Bodnar, J. M. Catov, and J. M. Roberts, “Racial/ethnic differences in the monthly variation of preeclampsia incidence,” American Journal of Obstetrics and Gynecology, vol. 196, no. 4, pp. 324.e1–324.e5, 2007. View at Publisher · View at Google Scholar · View at PubMed
  43. P. Magnus and A. Eskild, “Seasonal variation in the occurrence of pre-eclampsia,” British Journal of Obstetrics and Gynaecology, vol. 108, no. 11, pp. 1116–1119, 2001. View at Publisher · View at Google Scholar
  44. L. M. Bodnar, J. M. Catov, H. N. Simhan, M. F. Holick, R. W. Powers, and J. M. Roberts, “Maternal vitamin D deficiency increases the risk of preeclampsia,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 9, pp. 3517–3522, 2007. View at Publisher · View at Google Scholar · View at PubMed
  45. V. L. Bills, J. Varet, A. Millar, S. J. Harper, P. W. Soothill, and D. O. Bates, “Failure to up-regulate VEGFb165 in maternal plasma is a first trimester predictive marker for pre-eclampsia,” Clinical Science, vol. 116, no. 3, pp. 265–272, 2009. View at Publisher · View at Google Scholar · View at PubMed
  46. A. Cardus, S. Panizo, M. Encinas et al., “1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter,” Atherosclerosis, vol. 204, no. 1, pp. 85–89, 2009. View at Publisher · View at Google Scholar · View at PubMed
  47. J. Kong, G. Qiao, Z. Zhang, S. Q. Liu, and Y. C. Li, “Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium,” Kidney International, vol. 74, no. 12, pp. 1577–1581, 2008. View at Publisher · View at Google Scholar · View at PubMed
  48. A. Grey, J. Lucas, A. Horne, G. Gamble, J. S. Davidson, and I. R. Reid, “Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficiency,” The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 4, pp. 2122–2126, 2005. View at Publisher · View at Google Scholar · View at PubMed
  49. S. Silverberg, “Vitamin D deficiency and primary hyperparathyroidism,” Journal of Bone and Mineral Research, vol. 22, supplement 2, pp. V100–V104, 2007. View at Google Scholar
  50. E. G. Grubbs, S. Rafeeq, C. Jimenez et al., “Preoperative vitamin D replacement therapy in primary hyperparathyroidismml: safe and beneficial?” Surgery, vol. 144, no. 6, pp. 852–859, 2008. View at Publisher · View at Google Scholar · View at PubMed
  51. P. N. Sambrook, C. J. S. Chen, L. March et al., “High bone turnover is an independent predictor of mortality in the frail elderly,” Journal of Bone and Mineral Research, vol. 21, no. 4, pp. 549–555, 2006. View at Publisher · View at Google Scholar · View at PubMed
  52. K. E. Watson, M. L. Abrolat, L. L. Malone et al., “Active serum vitamin D levels are inversely correlated with coronary calcification,” Circulation, vol. 96, no. 6, pp. 1755–1760, 1997. View at Google Scholar
  53. M. R. Rubin, M. S. Maurer, D. J. McMahon, J. P. Bilezikian, and S. J. Silverberg, “Arterial stiffness in mild primary hyperparathyroidism,” The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 6, pp. 3326–3330, 2005. View at Publisher · View at Google Scholar · View at PubMed
  54. F. H. Puepet, E. I. Agaba, E. K. Chuhwak, and S. O. Ugoya, “Primary hyperparathyroidism presenting with severe hypertension in a middle aged Nigerian—a case report,” The Nigerian Postgraduate Medical Journal, vol. 15, no. 1, pp. 58–60, 2008. View at Google Scholar
  55. C. Gennari, R. Nami, and S. Gonnelli, “Hypertension and primary hyperparathyroidismml: the role of adrenergic and renin-angiotensin-aldosterone systems,” Mineral and Electrolyte Metabolism, vol. 21, no. 1–3, pp. 77–81, 1995. View at Google Scholar
  56. J. Bollerslev, T. Rosen, C. L. Mollerup et al., “Effect of surgery on cardiovascular risk factors in mild primary hyperparathyroidism,” The Journal of Clinical Endocrinology & Metabolism, vol. 94, no. 7, pp. 2255–2261, 2009. View at Publisher · View at Google Scholar · View at PubMed
  57. E. Rydberg, M. Birgander, A.-G. Bondeson, L. Bondeson, and R. Willenheimer, “Effect of successful parathyroidectomy on 24-hour ambulatory blood pressure in patients with primary hyperparathyroidism,” International Journal of Cardiology. In press. View at Publisher · View at Google Scholar · View at PubMed
  58. R. Jorde, J. Svartberg, and J. Sundsfjord, “Serum parathyroid hormone as a predictor of increase in systolic blood pressure in men,” Journal of Hypertension, vol. 23, no. 9, pp. 1639–1644, 2005. View at Google Scholar
  59. C. Fardella and J. A. Rodriguez-Portales, “Intracellular calcium and blood pressure: comparison between primary hyperparathyroidism and essential hypertension,” Journal of Endocrinological Investigation, vol. 18, no. 11, pp. 827–832, 1995. View at Google Scholar
  60. R. Scragg and C. A. Camargo Jr., “Scragg and camargo respond to “physical activity and vitamin D”,” American Journal of Epidemiology, vol. 168, no. 6, pp. 590–591, 2008. View at Publisher · View at Google Scholar
  61. S. J. Parikh, M. Edelman, G. I. Uwaifo, R. J. Freedman, M. Semega-Janneh, J. Reynolds, and J. A. Yanovski, “The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults,” The Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 3, pp. 1196–1199, 2004. View at Publisher · View at Google Scholar
  62. A. W. Norman, B. J. Frankel, A. M. Heldt, and G. M. Grodsky, “Vitamin D deficiency inhibits pancreatic secretion of insulin,” Science, vol. 209, no. 4458, pp. 823–825, 1980. View at Google Scholar
  63. G. Rammos, P. Tseke, and S. Ziakka, “Vitamin D, the renin-angiotensin system, and insulin resistance,” International Urology and Nephrology, vol. 40, no. 2, pp. 419–426, 2008. View at Publisher · View at Google Scholar · View at PubMed
  64. W. H. Taylor, “The prevalence of diabetes mellitus in patients with primary hyperparathyroidism and among their relatives,” Diabetic Medicine, vol. 8, no. 7, pp. 683–687, 1991. View at Google Scholar
  65. A. Kautzky-Willer, G. Pacini, B. Niederle, G. Schernthaner, and R. Prager, “Insulin secretion, insulin sensitivity and hepatic insulin extraction in primary hyperparathyroidism before and after surgery,” Clinical Endocrinology, vol. 37, no. 2, pp. 147–155, 1992. View at Google Scholar
  66. T. Ahlström, E. Hagström, A. Larsson, C. Rudberg, L. Lind, and P. Hellman, “Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women,” Clinical Endocrinology, vol. 71, no. 5, pp. 673–678, 2009. View at Publisher · View at Google Scholar · View at PubMed
  67. R. Scragg, M. Sowers, and C. Bell, “Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey,” Diabetes Care, vol. 27, no. 12, pp. 2813–2818, 2004. View at Publisher · View at Google Scholar
  68. M. Chonchol and R. Scragg, “25-hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey,” Kidney International, vol. 71, no. 2, pp. 134–139, 2007. View at Publisher · View at Google Scholar · View at PubMed
  69. A. G. Pittas, S. S. Harris, P. C. Stark, and B. Dawson-Hughes, “The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults,” Diabetes Care, vol. 30, no. 4, pp. 980–986, 2007. View at Publisher · View at Google Scholar · View at PubMed
  70. E. Liu, J. B. Meigs, A. G. Pittas et al., “Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults,” The Journal of Nutrition, vol. 139, no. 2, pp. 329–334, 2009. View at Publisher · View at Google Scholar · View at PubMed
  71. P. J. Matias, C. Ferreira, C. Jorge et al., “25-hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients,” Nephrology Dialysis Transplantation, vol. 24, no. 2, pp. 611–618, 2009. View at Publisher · View at Google Scholar · View at PubMed
  72. L. M. Resnick, “Calcium metabolism in hypertension and allied metabolic disorders,” Diabetes Care, vol. 14, no. 6, pp. 505–520, 1991. View at Google Scholar
  73. L. M. Resnick, R. K. Gupta, K. K. Bhargava, H. Gruenspan, M. H. Alderman, and J. H. Laragh, “Cellular ions in hypertension, diabetes, and obesity: a nuclear magnetic resonance spectroscopic study,” Hypertension, vol. 17, no. 6, part 2, pp. 951–957, 1991. View at Google Scholar
  74. V. Petrov and P. Lijnen, “Modification of intracellular calcium and plasma renin by dietary calcium in men,” American Journal of Hypertension, vol. 12, no. 12, part 1-2, pp. 1217–1224, 1999. View at Google Scholar
  75. L. Resnick, “The cellular ionic basis of hypertension and allied clinical conditions,” Progress in Cardiovascular Diseases, vol. 42, no. 1, pp. 1–22, 1999. View at Publisher · View at Google Scholar
  76. L. M. Resnick, “Cellular calcium and magnesium metabolism in the pathophysiology and treatment of hypertension and related metabolic disorders,” The American Journal of Medicine, vol. 93, no. 2A, pp. 11S–20S, 1992. View at Google Scholar
  77. G. Kamalov, J. P. Holewinski, S. K. Bhattacharya et al., “Nutrient dyshomeostasis in congestive heart failure,” The American Journal of the Medical Sciences, vol. 338, no. 1, pp. 28–33, 2009. View at Publisher · View at Google Scholar · View at PubMed
  78. H. Shi, Y. D. Halvorsen, P. N. Ellis, W. O. Wilkison, and M. B. Zemel, “Role of intracellular calcium in human adipocyte differentiation,” Physiol Genomics, vol. 3, no. 2, pp. 75–82, 2000. View at Google Scholar
  79. N. Begum, W. Leitner, J. E.-B. Reusch, K. E. Sussman, and B. Draznin, “GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca2+- induced inhibition of insulin-stimulated glucose transport,” Journal of Biological Chemistry, vol. 268, no. 5, pp. 3352–3356, 1993. View at Google Scholar
  80. M. B. Zemel, “Mechanisms of dairy modulation of adiposity,” The Journal of Nutrition, vol. 133, no. 1, pp. 252S–256S, 2003. View at Google Scholar
  81. M. B. Zemel, H. Shi, B. Greer, D. Dirienzo, and P. C. Zemel, “Regulation of adiposity by dietary calcium,” FASEB Journal, vol. 14, no. 9, pp. 1132–1138, 2000. View at Google Scholar
  82. M. B. Zemel and T. Sobhani, “Intracellular calcium modulation of cortisol production in human adipocytes,” FASEB Journal, vol. 17, p. A323, 2003. View at Google Scholar
  83. D. Duprez, M. De Buyzere, T. De Backer, and D. Clement, “Relationship between vitamin D and the regional blood flow and vascular resistance in moderate arterial hypertension,” Journal of Hypertension, vol. 11, pp. S304–S305, 1993. View at Google Scholar
  84. G. Targher, L. Bertolini, R. Padovani et al., “Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients,” Clinical Endocrinology, vol. 65, no. 5, pp. 593–597, 2006. View at Publisher · View at Google Scholar · View at PubMed
  85. G. M. London, A. P. Guérin, F. H. Verbeke et al., “Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency,” Journal of the American Society of Nephrology, vol. 18, no. 2, pp. 613–620, 2007. View at Publisher · View at Google Scholar · View at PubMed
  86. J. A. Sugden, J. I. Davies, M. D. Witham, A. D. Morris, and A. D. Struthers, “Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels,” Diabetic Medicine, vol. 25, no. 3, pp. 320–325, 2008. View at Publisher · View at Google Scholar · View at PubMed
  87. A. Ekmekci, N. Abaci, N. C. Ozbey et al., “Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism,” Journal of Endocrinological Investigation. In press.
  88. H. A. Bischoff-Ferrari, E. Giovannucci, W. C. Willett, T. Dietrich, and B. Dawson-Hughes, “Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes,” The American Journal of Clinical Nutrition, vol. 84, no. 1, pp. 18–28, 2006. View at Google Scholar
  89. E. Hyppönen and C. Power, “Vitamin D status and glucose homeostasis in the 1958 British birth cohort the role of obesity,” Diabetes Care, vol. 29, no. 10, pp. 2244–2246, 2006. View at Publisher · View at Google Scholar · View at PubMed
  90. M. Visser, D. J. H. Deeg, M. T. E. Puts, J. C. Seidell, and P. Lips, “Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission,” The American Journal of Clinical Nutrition, vol. 84, no. 3, pp. 616–622, 2006. View at Google Scholar
  91. R. B. Costello, “Vitamin D and health in the 21st century: federal initiatives to advance research,” The American Journal of the Medical Sciences, vol. 338, no. 1, pp. 34–39, 2009. View at Publisher · View at Google Scholar · View at PubMed
  92. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride, Food and Nutrition Board, Institute of Medicine. National Academy Press, Washington, DC, USA, 1997.
  93. J. N. Hathcock, A. Shao, R. Vieth, and R. Heaney, “Risk assessment for vitamin D,” The American Journal of Clinical Nutrition, vol. 85, no. 1, pp. 6–18, 2007. View at Google Scholar