Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

Table 1

Physiological parameters in Sham rats or 5/6 nephrectomized rats fed a hyperphosphatemia-inducing diet.

Parameters	Sham	5/6 NX-vehicle	5/6 NX-paricalcitol	5/6 NX-doxercalciferol
	—	—	0.33 𝜇g/kg	0.33 𝜇g/kg
Creatinine (mg/dL)	0.45 ± 0.03	1.28 ± 0.13***	1.57 ± 0.33**	1.29 ± 0.11***
BUN (mg/dL)	12.3 ± 0.3	59.1 ± 5.3***	60.1 ± 9.0***	60.5 ± 5.0***
Ionized Ca (mmil/L)	1.35 ± 0.02	1.13 ± 0.04**	1.26 ± 0.06^#	1.35 ± 0.03^###
Total serum Ca (mg/dL)	9.95 ± 0.13	8.99 ± 0.35**	10.1 ± 0.27^#	10.93 ± 0.23^**###
Total serum Pi (mg/dL)	6.50 ± 0.25	10.09 ± 0.76**	12.05 ± 1.89*	11.31 ± 1.05**
CaxPi ((mg/dL)^2)	64.8 ± 3.3	89.1 ± 4.0*	120.3 ± 18.2*	122.9 ± 10.6^***###
Serum PTH	142 ± 31	2504 ± 579**	1031 ± 382*	445 ± 135^##

Mean ± SEM; ^∗𝑃<.05, ^∗∗𝑃<.01, ^∗∗∗𝑃<.001 versus Sham; ^#𝑃<.05, ^##𝑃<.01, ^###𝑃<.001 versus NX-vehicle; 𝑛 = 8–11 per group.